BACKGROUND The Doberman Pinscher is one of the most common breeds of dogs to develop dilated cardiomyopathy (DCM), a primary heart muscle disorder characterized by myocardial dysfunction, cardiac arrhythmias, and congestive heart failure. In the Doberman Pinscher, the disease is typically adult onset, and a familial etiology has been suggested. HYPOTHESIS DCM in the Doberman Pinscher, is a fa...

About 30 different breeds are known to be affected but the Doberman is the breed most commonly associated with this disease. Of 15,000 Dobermans screened, more than 70% were found to be carriers of the disease in the United States. Fortunately, most of these are not clinically affected (i.e. we see no evidence of bleeding). However, the number of Dobermans with a history of bleeding appears to ...

BACKGROUND A congenital syndrome of hearing loss and vestibular dysfunction affects Doberman Pinschers. Its inheritance pattern is suspected to be autosomal recessive and it potentially represents a spontaneous animal model of an autosomal recessive syndromic hearing loss. HYPOTHESIS/OBJECTIVES The objectives of this study were to use whole genome sequencing (WGS) to identify deleterious gene...

Dilated cardiomyopathy (DCM) is a heterogeneous group of heart diseases with a strong genetic background. Currently, many human DCM cases exist where no causative mutation can be identified. DCM also occurs with high prevalence in several large dog breeds. In the Doberman Pinscher a specific DCM form characterized by arrhythmias and/or echocardiographic changes has been intensively studied by v...

Transplacental infection with Blastomyces dermatitidis is rare in humans and unknown in the dog. A Doberman pinscher bitch was diagnosed with blastomycosis 25 days after whelping. Clinical signs were noted after whelping and were progressive. All 9 pups were free of clinical signs and had negative urine Blastomyces antigen tests at 6 weeks of age and remained free of signs of illness through 11...

two male dogs at the age of 3 and 5 months of doberman pinscher and german shepherd breeds were referred to the veterinary hospital of ahvaz university with clinical signs of depression, vomiting, haemorrhagic diarrhoea, profound dehydration, fever and anorexia. the affected dogs had not the history of vaccination. concurrent infection of canine parvovirus and coronavirus was detected in dogs b...

BACKGROUND Dilated cardiomyopathy (DCM) in Doberman Pinschers is an autosomal dominant inherited disease. The prevalence of DCM in Doberman Pinschers of various age groups in Europe is currently unknown, but this information would be important to develop recommendations for screening programs. OBJECTIVES To evaluate the prevalence of cardiomyopathy in various age groups of Dobermans. ANIMAL...