BACKGROUND Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. No data on the dose proportionality of the pharmacokinetics of doxylamine are available, although this drug has been marketed in European countries for more than 50 years. OBJECTIVE The objective of this study was to evaluate and compare the d...

BACKGROUND Nausea and vomiting of pregnancy (NVP) is the most common medical condition in pregnancy, affecting up to 80% of expecting mothers. In April 2013 the FDA approved the delayed release combination of doxylamine succinate and -pyridoxine hydrochloride (Diclegis®) for NVP, following a phase 3 randomized trial in pregnant women. The fetal safety of this medication has been proven by numer...

BACKGROUND Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. The data available on the pharmacokinetic profile of doxylamine in humans are limited, notwithstanding that this drug has been marketed in European countries for more than 50 years. In fact, no data on the effect of food on the pharmacokinetic p...

• Vibrational spectra analysis of doxylamine succinate. N-H…O and C-H…O intermolecular hydrogen bonding interactions. Decrease in nonbonding electron density O is attributed to formation O-H bond. Doxylamine succinate accommodated the binding cavity SARS-CoV-2 main protease. In present work, experimental theoretical reports on electronic vibrational features (DXS) are presented. The were docume...

In this study a reversed phase HPLC method for rapid and simultaneous identification and quantification of doxylamine succinate, ephedrine sulfate, dextrometorphane hydrobromide, paracetamole and sodium benzoate in cough-cold syrup formulation was described. Separation was carried out on XTerra RP 18, Waters (150 mm x 4.6 mm column, 5 μm particle size). For the analysis of investigated substanc...

Nausea and vomiting in pregnancy (NVP) is common and often undertreated, in part due to fears of adverse effects of medications on the fetus during early pregnancy. In April 2013, the US Food and Drug Administration (FDA) approved doxylamine succinate 10 mg and pyridoxine hydrochloride (a vitamin B6 analog) 10 mg as a delayed-release combination pill called Diclegis for the treatment of NVP. Di...

A simple and rapid UV – Spectrophotometric method was developed and validated for the simultaneous estimation of Doxylamine succinate and Pyridoxine HCl in combined dosage forms. The said combination is used in treating morning sickness associated with pregnancy. For the simultaneous estimation of both drugs, 260 nm and 285 nm were selected as wavelength of analysis. The linearity range was tak...

Özet Doksilamin süksinat, etanolamin grubundan sedatif ve antikolinerjik etkileri olan bir antihistaminiktir. Genellikle uyku bozukluðu tedavisinde kullanýlan kýsa etkili bir ilaçtýr. Tek baþýna kullanýlabildiði gibi soðuk algýnlýðý için kullanýlan ilaçlarla da kombine halde bulunabilmektedir. Literatürde tek baþýna doksilamin süksinat intoksikasyonu ile ilgili az sayýda yayýn bulunmakta ve bun...