نتایج جستجو برای: Drug Solubility

تعداد نتایج: 607342  

Journal: :research in pharmaceutical sciences 0
saeed ghanbarzadeh aram khalili abolghasem jouyban shahram emami yousef javadzadeh mohammad solhi

low solubility and dissolution rate are the primary challenges in the drug development which substantially impact the oral absorption and bioavailability of drugs. due to the poor water solubility, albendazole (abz) is poorly absorbed from the gastrointestinal tract and shows low oral bioavailability (5%) which is a major disadvantage for the systemic use of abz. to improve the solubility and d...

Background and Aim: Application of topical tacrolimus in Vernal Keratoconjunctivitis is considered as an alternative to steroids. Due to the low aqueous solubility of the drug, preparing a solution of the drug has got particular importance. In the present study, tacrolimus eye drop was prepared using cyclodextrin, as a drug solubility enhancer. Materials and Methods: To improve the aqueous s...

Journal: :the iranian journal of pharmaceutical research 0
noushin bolourchian 1- department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- pharmaceutical sciences research center, shahid beheshti university of medical sciences, tehran, iran. mohammad mehdi mahboobian department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. simin dadashzadeh 1- department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- pharmaceutical sciences research center, shahid beheshti university of medical sciences, tehran, iran.

the purpose of the present study was to investigate the effect of polyethylene glycol (peg) molecular weights (6000, 12000 and 20000) as solid dispersion (sd) carriers on the dissolution behavior of simvastatin. sds with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. differential scanning calorimetry (dsc), x-ray diffraction (xrd), infrared spe...

Journal: :iranian journal of pharmaceutical research 0
s talegaonkar a yakoob khan r kishan khar f jalees ahmad z khan

paracetamol is a sparingly soluble bitter tasting drug. it is widely used as an analgesic and antipyretic. complexation of drug with different cyclodextrins (?, ? and hp-?-cd) was attempted to improve solubility of paracetamol. during the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of paracetamol w...

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

Journal: :the iranian journal of pharmaceutical research 0
harjeet singh department of pharmaceutics, rajiv academy for pharmacy, mathura, uttar pradesh, india. betty philip department of pharmaceutics, school of pharmacy, college of pharmacy and nursing, university of nizwa, birkat al mouz, nizwa 616, sultanate of oman. kamla pathak department of pharmaceutics, rajiv academy for pharmacy, mathura, uttar pradesh, india.

the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

Journal: :iranian journal of basic medical sciences 0
shaimaa m badr-eldin department of pharmaceutics and industrial pharmacy, faculty of pharmacy, king abdulaziz university, jeddah, ksa 2 department of pharmaceutics and industrial pharmacy, faculty of pharmacy, cairo university, cairo egypt tarek a. ahmed department of pharmaceutics and industrial pharmacy, faculty of pharmacy, king abdulaziz university, jeddah, ksa,department of pharmaceutics and industrial pharmacy, faculty of pharmacy, al-azhar university, cairo, egypt hatem r ismail department of pharmaceutics and industrial pharmacy, faculty of pharmacy, al-azhar university, cairo, egypt

objective(s): the aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-cd) and hydroxypropyl-β-cyclodextrin (hp-β-cd) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility.   materials and methods: phase solubility of aripiprazole with t...

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

A Yakoob Khan F Jalees Ahmad R Kishan Khar S Talegaonkar Z Khan

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

2011
A. Shayanfar A. Jouyban

Aqueous solubility of a drug/drug candidate is essential data in drug discovery, and an in silico method for predicting the aqueous solubility of drug candidates provides a valuable tool to speed up the process of drug discovery and development. This paper describes a simple quantitative structure property relationship (QSPR) model for predicting the aqueous solubility of drugs which is validat...

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