apatient was admitted to the hospital because of epistaxis, ecchymoses and gum bleeding with inr of 5.5. this patient had a known case of diabetes mellitus type ii, 5 years ago. the last dose of glibenclamide for managing signs and symptoms of diabetes mellitus was 20 mg/day. her medical history also showed that last month she was diagnosed with atrial fibrillation with normal left ventricular ...

        Apatient was admitted to the hospital because of epistaxis, ecchymoses and gum bleeding with INR of 5.5. This patient had a known case of diabetes mellitus type II, 5 years ago. The last dose of glibenclamide for managing signs and symptoms of diabetes mellitus was 20 mg/day. Her medical history also showed that last month she was diagnosed with atrial fibrillation with normal left vent...

BACKGROUND Gomisin G, isolated from herb Schisandra chinensis, exhibits anti-tumor activities. Therefore, Gomisin G is a drug candidate for anti-liver cancer therapy. AIMS To predict the metabolic behavior and metabolism-based drug-drug interaction of gomisin G. METHODS Molecular docking method was used. The crystal structure of CYP3A4 with the ligand ketoconazole was chosen from protein da...

Previous work on A -stable formulas is extended to A (a (-stable formulas, which are far more important in practice. Some important improvements in technique based on another interation method and an idea of Enright for the efficient handling of Jacobians are proposed. Implementation details and numerical examples are provided for a research-grade code.