Hedgehog is an evolutionarily conserved developmental pathway, widely implicated in controlling various cellular responses such as cellular proliferation and stem cell renewal in human and other organisms, through external stimuli. Aberrant activation of this pathway in human adult stem cell line may cause different types of cancers. Hence, targeting this pathway in cancer therapy has become in...

Background Previously we demonstrated the differentiation pathway of mouse, monkey and human ES cells to vascular cell components [1-3]. In addition, we showed the therapeutic potential of these ES-derived vascular cells. When transplanted in mouse hind-limb ischemia model, these cells were incorporated in host vessels in the ischemic lesion and contributed to host neovascular formations [4]. I...