Introduction: Radiotherapy plays a vital role in cancer treatment. To establish a new potency in radiosensitize tumor cells, delivery of High-Z materials is offered. To date, several simulation geometries have been applied to define simulation sets. The clustering of nanoparticles (NPs) within the cells is a prominent parameter usually ignored in simulation studies. <stro...

background: gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. objective: the aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles gnps with x-rays as a function of nanoparticle size and beam energy and ...

AIM To investigated the dose enhancement due to the incorporation of nanoparticles in skin therapy using the kilovoltage (kV) photon and megavoltage (MV) electron beams. Monte Carlo simulations were used to predict the dose enhancement when different types and concentrations of nanoparticles were added to skin target layers of varying thickness. METHODS Clinical kV photon beams (105 and 220 k...

Background: Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers.Objective: The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and ...

PURPOSE To identify which physical properties of nanoparticles are correlated with the survival fraction of cells exposed in vitro to low-energy protons in combination with nanoparticles. METHODS The Geant4 simulation toolkit (version 10.3) was used to model nanoparticles of different sizes (5-50 nm) and materials (Ti, Zr, Hf, Ta, Au, Pt), with or without an organic capping ensuring biocompat...

background: to enhance the dose to tumor, the use of high atomic number elements has been proposed. objective: the aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic x-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (gnps) in the tumor. meth...

geant4 is an open source simulation toolkit based on c++, which its advantages progressively lead to applications in research domains especially modeling the biological effects of ionizing radiation at the sub-cellular scale. however, it was shown that geant4 does not give a reasonable result in the prediction of antiproton dose especially in bragg peak. one of the reasons could be lack of a re...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. objective: the aim of this study is an investigating of percentage depth dose enhancement within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. methods: in this work...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. material and methods: in this study...

The GATE Monte Carlo simulation platform based on the GEANT4 toolkit has come into widespread use for simulating positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging devices. Here, we explore its use for calculating electron dose distributions in water. Mono-energetic electron dose point kernels and pencil beam kernels in water are calculated for dif...