introduction: response to tracheal tube during emergence of general anesthesia is a main concern. we aimed to compare the effect of remifentanil and lidocaine on response to tracheal tube during emergence of general anesthesia. materials and methods: in this randomized clinical trial, we enrolled 80 consecutive patients with american society of anesthesiology (asa) physical status i–ii, who und...

Introduction: Response to tracheal tube during emergence of general anesthesia is a main concern. We aimed to compare the effect of Remifentanil and Lidocaine on response to tracheal tube during emergence of general anesthesia. Materials and Methods: In this randomized clinical trial, we enrolled 80 consecutive patients with American Society of Anesthesiology (ASA) physical status I–II, who und...

Clinically, emergence from general anesthesia is viewed as a passive process where anesthetics are discontinued at the end of surgery and anesthesiologists wait for the drugs to wear off. The mechanisms involved in emergence are not well understood and there are currently no drugs that can actively reverse the state of general anesthesia. An emerging hypothesis states that brain regions that co...

BACKGROUND Although accumulating evidence suggests that arousal pathways in the brain play important roles in emergence from general anesthesia, the roles of monoaminergic arousal circuits are unclear. In this study, the authors tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane general anesthesia. METHODS Us...

BACKGROUND Orexin neurons regulate the sleep/wake cycle and are proposed to influence general anesthesia. In animal experiments, orexin neurons have been shown to drive emergence from general anesthesia. In human studies, however, the role of orexin neurons remains controversial, owing at least, in part, to the fact that orexin neurons are multifunctional. Orexin neurons regulate not only the s...

BACKGROUND Emergence delirium is a behavioral disturbance after general anesthesia in children and may distress both the patients and the primary caregivers, such as parents and medical staff, looking after the patients. Various medical and emotional interventions have been investigated to reduce emergence delirium; however, none are completely effective. This trial intends to assess whether th...

BACKGROUND A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia. METHODS In adult rats, we tested the effects of chloro-APB (D1 agonist) an...