This work was aimed to improve the efficacy of tacrolimus in treatment endotoxin-induced uveitis (EIU) using propylene glycol modified lipid vesicles termed as proglycosome nano-vesicles (PNVs). PNVs were prepared by film hydration method. Experimental rabbit eye induced an intravitreal injection 20 ?L endotoxin solution containing 100 ng lipopolysaccharide endotoxin. In vivo determined studyin...

Uveitis is a major cause of vision loss. Methotrexate (MTX) has been widely used in uveitis due to its relatively safe profile. The purpose of this study was to evaluate the effects of two different dosages of MTX via intra-vitreal administration for treatment of endotoxin induced uveitis (EIU) in an experimental model. Thirty-five healthy rabbits were randomly divided into four groups and all ...

tiight decades ago, a leading authority on uveitis hypothesized that many patients with uveitis suffered from a disease induced by bacterial toxins. Paradoxically, bacterial toxin in the form of endotoxin evolved as a conventional therapy for uveitis."" Now the conundrum has come full circle; currently, a subcutaneous or intraperitoneal injection of endotoxin serves as a standard model to induc...

Citation: Lin F -L, Ho J -D, Cheng Y -W, Chiou GCY, Yen J -L, Chang H -M, Lee T -H and Hsiao G (2018) Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation. Front. Pharmacol. 9:326. doi: 10.3389/fphar.2018.00326 Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular...

PURPOSE Interleukin-6 (IL-6) has been strongly implicated in anterior uveitis based on its presence in aqueous humor from infected eyes and its inflammatory effects when injected intravitreally into rats. We used IL-6-deficient mice to test further the hypothesis that IL-6 contributes to the development of endotoxin-induced uveitis. METHODS Uveitis was scored by histologic analysis of C3H/HeN...

PURPOSE To explore the effects of LPS pretreatment on endotoxin-induced uveitis and PI3K/AKT pathway. METHODS Endotoxin-induced uveitis was induced by a single subcutaneous injection of 200 μg LPS. For the endotoxin tolerance group, induction of EIU was preceded by daily subcutaneous injection of 0.1 mg/kg LPS for five days. Clinical scores were graded at 24 h after EIU under a slit lamp micr...

PURPOSE To investigate the role of oxidative stress in endotoxin-induced uveitis. METHODS Lipopolysaccharide was injected intravitreally into the right eyes of rabbits. Sterile saline was injected intravitreally into the left eyes as a control. Inflammation was assessed according to clinical score, aqueous humor cell count, and protein levels. Malondialdehyde, superoxide dismutase, glutathion...

BACKGROUND Injections of lipopolysaccharide in animal models generate acute anterior uveitis (also known as endotoxin-induced uveitis), but the effects of lipopolysaccharide injection are unknown in humans. We describe an unusual case in which acute anterior uveitis was dramatically activated subsequent to botulinum toxin injection in a patient with Behçet's disease but the acute anterior uveit...

Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in e...