background autoimmune hepatitis (aih) is a form of chronic hepatitis with unclear causative factors and is characterized by immunological and auto-immunological manifestations. several extrahepatic manifestations, such as other autoimmune disorders, are associated with aih. aih with dermatological conditions as the initial manifestation is rare. we report the case of aih in which erythema nodos...

the clinical and histological feature of 52 years old woman with erythema induratum are discribed the characteristic cutaneous lesions on the legs of middle-aged woman were violaceous, indurated nodules, 1 to 2 cm in diameter which were painful, occasionally ulcerated and could heal with scarring. the diagnosis was confirmed by a strongly positive tuberculin test, histologic feature and by clea...

Rowell syndrome (RS) describes the rare presentation of EM like lesions found in association with a diagnosis lupus erythematosus (LE). Major diagnostic criteria includes LE, EM, and anti-nuclear antibodies. Minor chilblains, anti-Ro/anti-La antibodies, rheumatoid factor. We present 26-year-old white male seen consultation for chronic erythema multiforme (EM) duration 6 months unresponsive to t...

while an important infectious disease in the united states and eurasia, lyme disease is rare in iran. we present a 9-year old boy admitted in children’s medical center in december 2001 with final diagnosis of lyme disease. on admission he showed arthritis and a history of previous skin lesions. serologic examination including enzyme–linked immunosorbent assay and western blot was positive for l...

Generalized granuloma (GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is flesh colored, annular, grouped papules. They usually are on the extremities especially on the lateral or dorsal surfaces of the fingers, hands, wrists, ankles, and insteps. Several clinical manif...

objective(s):genetic and environmental factors are involved in the pathogenesis of systemic lupus erythematosus (sle). autoreactive lymphocytes are cleared through apoptosis and any disturbance in the apoptosis or clearance of apoptotic cells may disturb tolerance and lead to autoimmunity. vitamin d has anti-proliferative effects and controls cell cycle progression. in this study we investigate...