Expression of microRNA genes is profoundly altered in cancer but their role in the development of androgenindependent prostate cancer has received limited attention as yet. In this study, we report a functional impact in prostate cancer cells for overexpression of the microRNAmiR-616, which occurred consistently in cells that were androgen-independent (AI) versus androgen-dependent (AD). miR-61...

Lung cancers with neuroendocrine (NE) features are often very aggressive but the underlying molecular mechanisms remain elusive. The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that is involved in the pathogenesis of lung cancers with NE features (NE-lung cancers). Here we report the definition of the microRNAmiR-375 as a key downstream effector of ASH...

Alman ceza hukukunda intihar etmek suç değildir. Suç olmayan bir eyleme iştirak edenler de hukukundaki bağlılık kuralı gereğince cezalandırılamaz. Ancak kamuoyunda ve bilim çevrelerinde intihara yardım niteliğindeki bazı eylemlerin cezalandırılması gerektiği konusu, yoğun olarak tartışılmaktadır. Bu tartışmalar neticesinde 2015 yılında, belli eylemler Ceza Kanunu’nun 217. paragrafı ile cezai ya...

This edition of the Journal starts with the big questions in psychiatry: what is a diagnosis? And how does one justify treatment against the will of the individual? The next version of the World Health Organization’s bible, the ICD–11, is being prepared at the same time as the American Psychiatric Association’s fifth edition of the DSM. The push for harmonising these two different systems is di...