Fej'{e}r  Hadamard  inequality is generalization of Hadamard inequality. In this paper we prove certain Fej'{e}r  Hadamard  inequalities for $k$-fractional integrals. We deduce Fej'{e}r  Hadamard-type  inequalities for Riemann-Liouville fractional integrals. Also as special case Hadamard inequalities for $k$-fractional as well as fractional integrals are given.

The endotoxin component of organic dusts causes acute reversible airflow obstruction and airway inflammation. To test the hypothesis that endotoxin alone causes airway remodeling, we have compared the response of two inbred mouse strains to subchronic endotoxin exposure. Physiological and biological parameters were evaluated after 1 day, 5 days, or 8 wk of exposure to endotoxin [lipopolysacchar...

In this article, we define a new class of convexity called generalized $(h-m)$-convexity, which generalizes $h$-convexity and $m$-convexity on fractal sets $\mathbb{R}^{\alpha}$ $(0<\alpha\leq 1)$. Some properties are discussed. Using local fractional integrals Hermite-Hadamard (H-H) Fej\'er-Hermite-Hadamard (Fej\'er-H-H) types inequalities. We also obtained result the Fej\'er-H-H type for func...

Achieving the control of bovine tuberculosis (bTB) would require the discovery of an efficient combined immunodiagnostic and vaccine strategy. Since in vivo experiments on cattle are not ethically and economically acceptable there is a need for a cost-effective animal model capable of reproducing, as closely as possible, the physiopathology of bTB to (i) better characterize the cellular and mol...

Mice are themost commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy in a way that is more like human TB. Because the development of such pathology requires time, we investigated the effect of infection incubation per...

Pyrazinamide (PZA) is one of only two sterilizing drugs in the first-line antituberculosis regimen. Its activity is strongly pH dependent; the MIC changes by several orders of magnitude over a range of pH values that may be encountered in various in vivo compartments. We recently reported selective inactivity of PZA in a subset of C3HeB/FeJ mice with large caseous lung lesions. In the present s...

Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy in a way that is more like human TB. Because the development of such pathology requires time, we investigated the effect of infection incubation pe...

A drug combination comprised of methotrexate (1 mg/kg given on Day 2 of the sensitization period) followed in 1 hr by 5-fluorouracil (50 mg/kg) is capable of potentiative suppres sion of humoral antibody production without concomitant inhibition of cell-mediated immunity. Thus, this combination suppressed 19 S hemolytic antibody production in C3HeB/FeJ mice by 88% but had no inhibitory effect u...

O(6)-methylguanine (O(6)mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleterious effects of O(6)mG through a direct reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT). However, the contribution of O(6)mG to carcinogenesis, in the absence of known exposure to agents th...

Proposed mechanisms for the evolution of population stability include group selection through longterm persistence, individual selection acting directly on stability determining the demographic parameters, and the evolution of stability as a by-product of life-history evolution. None of these hypotheses currently has clear empirical support. Using two sets of Drosophila melanogaster populations...