Background: Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has been considered as a promising milestone in liver fibrosis treatment. However, low amounts of homing are a major obstacle. We aimed to investigate the role of melatonin pretreatment in BMMSC homing into experimental liver fibrosis. Methods: BMMSCs were obtained, grown, propagated and preconditioned with 5 &micro...

background this prospective study was designed to examine the role of fibrosis staging on selection and success of treatment options for autoimmune hepatitis (aih). materials and methods the project was conducted on 110 selected aih patients who, based on the results of liver biopsy, had been assigned into one of the three groups (mild, stages 1 and 2, moderate, stages 3 and 4, and severe, stag...

Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...

Introduction: The liver fibrosis is caused by extracellular accumulation of cluster, glycos amino glycans and proteoglycans, which this extracellular accumulation may limit the penetration and molecular movement of water in the tissue, so the Diffusion weighted imaging(DWI) technique is due to the sensitivity to the movement and release of water molecules Can show this restrict...

Macromolecular proton fraction (MPF) and T1rho maps for two representative patients with F0 F2 stage fibrosis as confirmed by liver histology. (A) MPF from a patient fibrosis, (B) (C) the same (D) fibrosis. Jian Hou et al. (485–492).

introduction: bronchiectasis is a common problem in children especially under 5 years. early diagnosis of disease and its causes could be useful in early treatment and preventing probable complications. this study aimed at evaluating the cystic fibrosis (cf) in patients with  bronchiectasis. methods: in a cross-sectional study, 374 children with bronchiectasis were studied. the diagnosis was ma...

treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (pf) which is a commonly progressive and untreatable dieases. caffeic acid phenethyl ester (cape) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). in th...

conclusions hcv coinfection, older age and ast were associated with lf in patients with hiv infection. objectives the aim of this cross-sectional study was to identify factors associated with liver fibrosis (lf) in patients with hiv monoinfection and hiv-hcv coinfection. patients and methods we analyzed lf by transient elastometry ([te], fibroscan) in three groups of patients (hiv, hiv-hcv and ...

objective(s):to clarify the protective effects of cichorium glandulosum (cg) extracts on thioacetamide (taa)-induced rat hepatic fibrosis. materials and methods: the dry roots of cg were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (cg-v), ethyl acetate extract (cg-vi) and n-butyl alcohol extract (cg-vii). thirty-six wistar rats were random...

the influence of glycosaminoglycans (gag) on collagen fibrillogenesis in vitro was investigated. gag and collagen were isolated from the liver of rats treated with carbon tetrachloride at various time intervals (3-16 weeks). it was found that gag obtained from the fibrotic liver accelerated collagen fibril formation. this effect was more evident in a solution of type i collagen than type iii co...