background: urinary tract infections (utis) are one of the most common infectious diseases diagnosed all over the world. meanwhile most episode of utis are caused by escherichia coli (up to 85%) and frequently fluoroquinolones are preferred as initial agents for empiric therapy of utis. widespread use of fluoroquinolones has resulted in an increasing incidence of resistance these agents all ove...

background assessment of resistance genes is imperative, as they become disseminated to bacterial flora in plants and to the indigenous bacterial community, and thus ultimately contributes to the clinical problems of antibiotic resistant pathogens. objectives the research was to assess the antibiotic characteristics and incidence of sul3 genes of stenotrophomonas maltophilia isolates recovered ...

Fluoroquinolones are known widely used synthetic antibacterial agents. Generally, there were some obstacles associated with their therapeutic use. Moreover, many research studies all over the world proved variable biological effects of fluoroquinolones such as antituberculosis, anticancer, or even antiviral activities. The current review is focused on modifications that occurred in fluoroquinol...

background: antibiotic therapies used in treatment of many diseases have adverse effects on fertility. this review analyzes previous comparative studies that surveyed the effects of two common groups of antibiotics on male fertility. objective: to evaluate histo-pathological effects of fluoroquinolones and aminoglycosides on sperm parameters and male reproductive tissue. materials and methods: ...

Appropriate prescribing practices for fluoroquinolones are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children becomes better defined. Earlier recommendations for systemic therapy remain; expanded uses of fluoroquinolones for the treatment of certain infections are outlined in this re...

OBJECTIVE To review the pharmacokinetics, efficacy, and safety of fluoroquinolones in children. DATA SOURCES A MEDLINE search (January 1966-March 1998) was conducted for relevant literature. STUDY SELECTION AND DATA EXTRACTION Data from compassionate use and published studies were reviewed for the assessment of pharmacokinetics, efficacy, and safety of fluoroquinolones in children. DATA S...

This study analyses consumption patterns of fluoroquinolones in treating respiratory tract infections in ambulatory care in Belgium and describes susceptibility of Streptococcus pneumoniae isolates to fluoroquinolones. Consumption data were obtained from IMS Health. Pneumococcal resistance was investigated in 600 blood isolates collected from 1998 to 2003. Although consumption of fluoroquinolon...

mycoplasmosis caused by mycoplasma has immensely reduced the performance of commercial animal husbandry, along with prevalence and increase of drug resistance in mycoplasma, thus new agents and therapies are urgently needed. triclosan is a broad spectrum antimicrobial agent with a favorable safety profile. in the present study, we tested the antimycoplasmal activity of triclosan alone, as well ...

background rapid detection of resistant strains of helicobacter pylori in human clinical samples is of major importance in clinical settings. inability of conventional clinical laboratory techniques in detection of these strains usually leads to failure of prescribed therapeutic regimens. objectives the aim of this study was designing a simple and rapid allele-specific pcr (as-pcr)-based method...