Krebs (1931) stated that, in ankylosing spondylitis, sacro-iliac changes appeared early in radiographs and were almost constant. Since that time the attention of all those interested in the clinical aspects and pathogenesis of the disease has been focused on these radiological changes. Scott (1936) laid great stress on the value of radiological changes in early diagnosis of the disease, and lau...

Forestier and Rotes-Querol (1950) described a disease of the spinal column, occurring mostly in elderly persons and frequently mistaken for ankylosing spondylitis, which they designated "hyperostose ankylosante vertebrale senile". The clinical manifestations of this disease are characterized by a decreased mobility of the spine, caused by bony outgrowths bridging the anterior and lateral faces ...

A 63-year-old male was referred to our department from Primary Care with odinophagia of several years’ evolution, with episodes of fluctuating dysphonia and dyspnoea. He has a history as a smoker and moderate drinker, COPD, hiatus hernia with gastroesophageal reflux and ankylosing spondulitis. Physical exploration showed no changes to the larynx, with protrusion of the posterior wall of the hyp...

A 63-year-old male was referred to our department from Primary Care with odinophagia of several years’ evolution, with episodes of fluctuating dysphonia and dyspnoea. He has a history as a smoker and moderate drinker, COPD, hiatus hernia with gastroesophageal reflux and ankylosing spondulitis. Physical exploration showed no changes to the larynx, with protrusion of the posterior wall of the hyp...

The article by Roberts et al is important because it points to potential occurrence of side effects due to paracetamol, some of which are life-threatening. However, we have some doubts about the conclusions because it is not certain that they really show the responsibility of the drug itself in the adverse events mentioned. Although the authors well define methodological limitations of the arti...