a 3-year-old arabian colt was presented for a major gingiva wound at the right rostral part of mandible. after clinical assessments, rostral mandibular fracture was determined. stabilization of fractured region was achieved via cerclage wire application under general anesthesia. fixation wires were left in place for 6 weeks. a 3 -month follow up revealed complete fracture healing. the purpose o...

in order to study the effect of ultrasound (us) on bone healing, a complete transverse fracture was made in the right radius of adult male rabbits by a cutter. 52 rabbits were used: group i. control (n= 17): group 2. test (n:=: 15): group 3, intact (n= i) and group 4 (n= 12) who were examined only for evaluation of the cutter effects in detail. 7 animals were operated with a gigli saw. the test...

Healing of the bone is different with the other part of the body. Fracture healing is actually a bone regeneration with no scar tissues, where as in wound healing, injured tissue is replaced by  connective tissue which became a scar, Traditionally fracture healing is divided in to 4 stages: 1) Stage of inflammation; 2) Stage of soft callus; 3) Stage of hard callus and 4) Stage of remodeling. In...

background: effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. however, the efficacy of estrogen treatment on bone healing is not well investigated. the drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. the aim of this study was to investigate the effect of local an...

Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing osteoporotic fracture healing. To determine the biomechanical recovery process during osteoporotic fracture healing, studies on osteoporotic femur fra...

PURPOSE OF REVIEW Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In d...

Impaired fracture healing in aged females is still a challenge in clinics. MicroRNAs (miRNAs) play important roles in fracture healing. This study aims to identify the miRNAs that potentially contribute to the impaired fracture healing in aged females. Transverse femoral shaft fractures were created in adult and aged female mice. At post-fracture 0-, 2- and 4-week, the fracture sites were scann...

Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fract...

background: the fracture healing is impaired in osteoporosis. piper sarmentosum is a plant, which contains potent antioxidant, naringenin that may enhance fracture healing. the present histological study aimed to determine the effects of water extract of piper sarmentosum on the late phase of fracture healing in estrogen-deficient rats. methods: twenty four female sprague-dawley rats (200-250 g...

BACKGROUND AND PURPOSE A variety of risk factors have been hypothesized to contribute to the development of fracture-healing complications; however, population-based estimates of the strength of these risk factors are limited. In this case-control study, we evaluated patient-related risk factors for fracture-healing complications. METHODS Using the United Kingdom General Practice Research Dat...