Topical therapy of onychomycosis, a fungal infection of nail plate and/or nail bed, offers an attractive alternative to treatment with systemic antifungals. To treat fungal infections locally, antifungal-loaded nail lacquers have been prepared in our laboratory. Franz diffusion cells have been used to investigate drug permeation from such lacquers into and through the nail plate in vitro. Altho...

Nowadays, the intranasal route has become a reliable alternative for drug administration to systemic circulation or central nervous system. However, there are no official in vitro diffusion and dissolution tests especially investigation of nasal formulations. Our main goal was study compare well-known lesser-known permeability method, order ascertain which suitable determination through mucosa ...

The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTIR-ATR cell was developed for non-invasive real time measurements of drug diffusion. The diffusion...

Synthetic membranes used in Franz diffusion cells for topical formulation quality assessment should provide least resistance to drug diffusion. In this study, the diffusion rates of ibuprofen across thirteen membranes were determined using Franz diffusion cells. Correlation of the membrane thickness, pore size and MWCO with drug fluxes was also made. The drug diffusion results showed that the p...

Transdermal diffusion studies of a polyherbal ointment were carried out in vito using franz- Diffusion cell and microbial one inhibition diameter as drug release monitoring parameters. Out of the three ointment base prepared, (Hydrocarbon Base (HB), surfactant Base (SB), Surfactant Base + (Penetration Enhancer (10 % DMSO) SBPE), we observed that SBPE possesses maximum drug release capacity, as ...

Abstract: The objective of this study was to fabricate topical formulations of diclofenac diethylamine (DD) using isopropyl myristate (IPM) and isopropyl palmitate (IPP) as permeation enhancers. Franz cell and bacterial cellulose were used as analytical instrument and diffusion membrane, respectively. Permeation enhancers exhibited significant effect on the permeation characteristics of DD. It ...

ABSTRACT The present study was undertaken to determine the diffusion rate of a drug from a semisolid dosage form using different membranes and to explore a membrane and to find out the comparative membrane identical to human skin with respect to diffusion rate of the drug from the selected dosage form. In the present study, Franz cell was used to carry out the diffusion study through fuzzy rat ...

Franz cells (2-chambered, air/fluid phase static diffusion devices, previously used for the study of drugs across viable human skin) are utilized for the first time to investigate the process of infection of human skin by Schistosoma mansoni cercariae. Skin obtained from cosmetic surgery sources was used in the Franz cells to describe the temporal dynamics of the early interaction of cercariae ...

The main objective of this paper was to manipulate the Nano Fibrous Scaffold "NFS" surface roughness to achieve a new transdermal drug release profile. To assess the intrinsic mechanical properties of Nylon 6 or polycaprolactam, such as its proper resiliency, it was considered as the matrix. Cetirizine was used as a drug model and was loaded (1% w/v) to polymer solution (30%w/v) before spinning...

The main objective of this paper was to manipulate the Nano Fibrous Scaffold "NFS" surface roughness to achieve a new transdermal drug release profile. To assess the intrinsic mechanical properties of Nylon 6 or polycaprolactam, such as its proper resiliency, it was considered as the matrix. Cetirizine was used as a drug model and was loaded (1% w/v) to polymer solution (30%w/v) before spinning...