a series of angiotensin ii (a ii) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to qsar analysis using hansch and fujita-ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. several qsar model were obtained using stepwise regression analysis. two models from both the method...

      A series of angiotensin II (A II) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to QSAR analysis using Hansch and Fujita-Ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. Several QSAR model were obtained using stepwise regression analysis. Two models from both the ...

The present work deals with the chemometric modeling of antioxidant molecules belonging to the class of flavone derivatives employing the quantitative structure-activity relationship (QSAR) technique. A QSAR model was initially built based on the Fujita-Ban method with the training set molecules. Due to the inability of the Fujita-Ban type model to predict satisfactorily the activity of the tes...

As a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model...

Takeshi Toyoda ([email protected]) Tetsuya Tsukamoto ([email protected]) Masami Yamamoto ([email protected]) Hisayo Ban ([email protected]) Noriko Saito ([email protected]) Shinji Takasu ([email protected]) Liang Shi ([email protected]) Ayumi Saito ([email protected]) Seiji Ito ([email protected]) Yoshitaka Yamamura ([email protected]) Akiyoshi Nishikawa (nishikaw...

The cyclooxygenase-2 enzyme inhibition activity of 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives is quantitatively analyzed through Fujita-Ban and Hansch type of approaches. The analyses have helped to ascertain the role of different substituents in explaining the observed inhibitory activity of these congeners. From both approaches it is revealed that more hydrophobic susbtituents at 4...

Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296; Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192; School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Correspondence to: Dr. Kan Shimpo, Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296, Japan. Tel: +...