نتایج جستجو برای: GABA-A receptors
تعداد نتایج: 13488458 فیلتر نتایج به سال:
introduction: pro-inflammatory chemokines and cytokines such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...
introduction: fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. estrogens affect anxiety through neurochemical systems such as gaba-a receptors. in this study the effects of fennel on gaba-a and estrogen receptors in anxiety were investigated. methods: adult female wistar rats weighing (180±20 g) were divided into 8 groups. groups received saline, fennel (200, 500,...
Introduction: Fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. Estrogens affect anxiety through neurochemical systems such as GABA-A receptors. In this study the effects of fennel on GABA-A and estrogen receptors in anxiety were investigated. Methods: Adult female Wistar rats weighing (180±20 g) were divided into 8 groups. Groups received saline, fennel (200, ...
social anxiety disorder (sad) is the one of the most common anxiety disorders. despite its high prevalence, the disorder is still considerably undiagnosed and untreated. the disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (gaba) s...
Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder....
Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...
Background & Objective: The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain neurons. GABA(A) receptors have bidirectional roles in controlling nociception and are abundant in the parabrachial region . We examined the effects of bilateral intra parabrachial microinjection of different doses of the GABA(A) receptor agonist, muscimo...
spreading depression (sd), discovered by leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes. sd appears to act through several mechanisms and receptors which have not completely understood. here, we studied the effect of inhibitory system in animal model of sd using immunohistochemistry technique. after imp...
objective(s) the effect of testosterone on anxiety-like behaviors has been the subject of some studies. there is evidence that testosterone modulates anxiety via gaba (gama aminobutyric acid) and gabaergic system. the involvement of gabac receptors in those effects of testosterone on anxiety-like behaviors of the rats was investigated in the present study. materials and methods a group of rats ...
background: γ-aminobutyric acid (gaba) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (cns). there are two major classes of gaba receptors: gabaars and gababrs. the gabaa receptor is derived from various subunits such as alpha1-alpha 6, beta1-beta 3, gamma1-gamma 4, delta, epsilon, pi, and rho1-3. intensive research has been performed to un...
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