نتایج جستجو برای: GAGS

تعداد نتایج: 1000  

2013
Nur Afiqah Bahrom KNS Sirajudeen George W Yip Aishah A Latiff Farid Che Ghazali

In this article, the novel inventive steps for the extraction and quantification of sulfated glycosaminoglycan (GAG) from Acanthaster planci starfish, generally known as crown-of-thorns (COT), are reported. Starfish have been implicated with collagenous distributions within their body anatomy, thus making it a prima facie fact searching for the possibility that GAGs can be isolated from COT. In...

2003
Chang-Lin Dou Joel M. Levine

Glycosaminoglycans (GAGS), the carbohydrate moieties of proteoglycans, are thought to be positive and negative regulators of axonal growth. The physiological role of GAGS is controversial as some studies have shown that GAGS inhibit cell adhesion and neurite elongation (Exp Neurol 109:111, 1990) whereas other studies have reported a growth stimulatory effect of GAGS (Development 114:17, 1992). ...

Journal: :Cardiovascular Diabetology 2009
Juying Han Fuming Zhang Jin Xie Robert J Linhardt Linda M Hiebert

BACKGROUND Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and atherosclerosis. Decreased HSPG may contribute to diabetic endothelial injury. Decreased tissue HS in diabetes has been reported, however, endothelial HS changes are poorly studied. ...

Journal: :Glycobiology 2013
Paul L DeAngelis Jian Liu Robert J Linhardt

Glycosaminoglycans (GAGs) are complex polysaccharides composed of hexosamine-containing disaccharide repeating units. The three most studied classes of GAGs, heparin/heparan sulfate, hyaluronan and chondroitin/dermatan sulfate, are essential macromolecules. GAGs isolated from animal and microbial sources have been utilized therapeutically, but naturally occurring GAGs are extremely heterogeneou...

Journal: :Medical journal of Zambia 2022

Abstract
 Hunter syndrome is one of the Mucopolysaccharidosis (MPS), type II. It a rare genetic disorder due to deficiency in enzyme Iduronate 2-sulphatase. This leads accumulation glycosaminoglycans (GAGs) dermatan sulphate and heparan sulphate. The GAGs accumulate both intracellularly extracellularly, leading abnormalities different organ systems body. definitive diagnosis requires bioch...

Journal: :FEBS letters 2014
Armelle Tchoumi Neree Phuong Trang Nguyen David Chatenet Alain Fournier Steve Bourgault

Glycosaminoglycans (GAGs) contribute to the cellular uptake of cationic cell-penetrating peptides (CPPs). However, molecular details about the contributions of GAGs in CPP internalization remain unclear. In this study, we examined the cellular uptake mechanism of the arginine-rich CPP pituitary adenylate-cyclase-activating polypeptide (PACAP). We observed that the uptake efficacy of PACAP is de...

Journal: :Frontiers in bioscience 2016
Rafael S Aquino Pyong Woo Park

Glycosaminoglycans (GAGs) are complex linear polysaccharides expressed in intracellular compartments, at the cell surface, and in the extracellular environment where they interact with various molecules to regulate many cellular processes implicated in health and disease. Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial pathogens, including viruses, bacteria, pa...

Journal: :The Journal of biological chemistry 2007
Dejan Caglic Jerica Rozman Pungercar Gunnar Pejler Vito Turk Boris Turk

Lysosomal cysteine cathepsin B participates in numerous diverse cellular processes. In acquiring its activity, the proregion, which blocks the substrate-binding site in the proenzyme, needs to be cleaved off. Here we demonstrate that polyanionic polysaccharides, glycosaminoglycans (GAGs), can accelerate the autocatalytic removal of the propeptide and subsequent activation of cathepsin B. We sho...

Journal: :Pacific Journalism Review : Te Koakoa 2006

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