نتایج جستجو برای: GDF8

تعداد نتایج: 96  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2018
Ryan G Walker Jason C McCoy Magdalena Czepnik Melanie J Mills Adam Hagg Kelly L Walton Thomas R Cotton Marko Hyvönen Richard T Lee Paul Gregorevic Craig A Harrison Thomas B Thompson

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small-angle X-ray scattering and mutagenesis, we characterized the interactions of GDF8 with its prodomain. Our results show that the prodomain:GDF8 complex can exist in a fully latent s...

2017
Ryan G. Walker Jason C. McCoy Magdalena Czepnik Melanie J. Mills Adam Hagg Kelly L. Walton Thomas Cotton Marko Hyvönen Richard T. Lee Paul Gregorevic Craig A. Harrison Thomas B. Thompson

Growth/differentiation factor 8 (GDF8) or myostatin negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small angle X-ray scattering and mutagenesis, we characterized the interactions of GDF8 with its prodomain. Our results show that the prodomain:GDF8 complex can exist in a fully latent sta...

2015
Daniel Horbelt Jan H. Boergermann Apirat Chaikuad Ivan Alfano Eleanor Williams Ilya Lukonin Tobias Timmel Alex N. Bullock Petra Knaus

GDF8, or myostatin, is a member of the TGF-β superfamily of secreted polypeptide growth factors. GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro. We found that GDF8 signaling was inhibited by the small molecule ATP competitive inhibitors dorsomorphin and LDN-193189. These compounds were previously shown to be potent inhibitors of BMP signaling by binding to the BMP t...

2017
Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J Murphy George D Yancopoulos Jesper Gromada

Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad TGF-β inhibition suggests another family member negatively regulates muscle mass, and its blockade enhances muscle growth seen with GDF8-specific inh...

Journal: :The EMBO journal 2018
Viet Q Le Roxana E Iacob Yuan Tian William McConaughy Justin Jackson Yang Su Bo Zhao John R Engen Michelle Pirruccello-Straub Timothy A Springer

Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understand structural mechanisms underlying latency and activation of GDF8. Negative stain electron microscopy (EM) of precursor and latent pro-complexes rev...

2017
Christoph Wallner Stephanie Abraham Marcus Lehnhardt Bjorn Behr

introduCtion: The healing capacity of bone can be substantially reduced by metabolic diseases such as diabetes mellitus. Apart from an epidemiological component of metabolic diseases the present poor therapy of diabetic associated bone healing deficiencies demands adequate new treatment options. In previous studies we were able to show a massive impairment of bone regeneration in diabetic bone....

Journal: :Physiological genomics 2004
W Huygens M A Thomis M W Peeters J Aerssens R Janssen R F Vlietinck G Beunen

This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myostatin pathway were genotyped. Muscle mass was estimated by anthropometric mea...

Journal: :Polish journal of veterinary sciences 2011
Z Wicik T Sadkowski M Jank T Motyl

GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the DNA microarray technique. Treatment with exogenous GDF8 strongly affected the growth and developm...

Journal: :The Journal of biological chemistry 2008
Katalin Kondás György Szláma Mária Trexler László Patthy

WFIKKN1 and WFIKKN2 are large extracellular multidomain proteins consisting of a WAP, a follistatin, an immunoglobulin, two Kunitz-type protease inhibitor domains, and an NTR domain. Recent experiments have shown that WFIKKN2 protein binds mature GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin (Hill, J. J., Qiu, Y., Hewick, R. M., and Wolfman, N. M. (20...

Journal: :molecular biology research communications 2014
younes miar abdolreza salehi davood kolbehdari seyed ahmad aleyasin

myostatin or growth and differentiation factor 8 (gdf8), has been known as the factor causing double muscling phenotypes in which a series of mutations make the myostatin protein inactive, hence disabling it to regulate the deposition of muscle fibre. this phenotype happens with high frequency in a breed of sheep known as the texel. quantitative trait loci (qtl) studies show that a portion of t...

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