γ-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. Employing GGH immunohistochemistry on a tissue microarray with 12,427 prostate cancers, we found that GGH expression was negative to low in normal prostate epithelium, whereas 88.3% of our 10,562 interpretable cancers showed GGH expressi...

Intracellular metabolism of methotrexate (MTX) to MTX-polyglutamates (MTXPG) is one determinant of cytotoxicity. Steady-state accumulation of MTXPG seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them. Overexpression of GGH would be expected to decrease intracellular MTXPG, the...

Recently, Hu and Jia presented an efficient attack on the GGH map. They show that the MPKE and WE based on GGH with public tools of encoding are not secure. Currently, an open problem is to fix GGH with functionality-preserving. We present a new construction of multilinear map using ideal lattices, which maintains functionality of GGH with public tools of encoding, such as applications of GGH-b...

We examined the effects of feeding guar-gum hydrolysate (GGH), a highly fermentable form of dietary fibre with low viscosity, on Ca absorption in the small and large intestines in rats under conditions in which gastric acid secretion was suppressed by a proton pump inhibitor, omeprazole. We also examined the role of the caecum in influencing these effects. The study was designed in a 2 x 2 x 2 ...

A water-soluble fluorescent probe (C-GGH) was used for the highly sensitive and selective detection of cyanide (CN(-)) in aqueous media based on the displacement strategy. Due to the presence of the recognition unit GGH (Gly-Gly-His), the probe C-GGH can coordinate with Cu(2+) and consequently display ON-OFF type fluorescence response. Furthermore, the in situ formed nonfluorescent C-GGH-Cu(2+)...

GGH class of public-key cryptosystems relies on computational problems based on the closest vector problem (CVP) in lattices for their security. The subject of lattice based cryptography is very active and there have recently been new ideas that revolutionized the field. We present EEH, a GGH-Like public key cryptosystem based on the Eisenstein integers Z [ζ3] where ζ3 is a primitive...

Methotrexate (MTX) is an antifolate that is widely used for the treatment of childhood acute lymphoblastic leukemia (ALL) and a number of other malignant and nonmalignant diseases. Within cells, MTX is metabolized to more active methotrexate polyglutamates (MTXPG), and these polyglutamates are subsequently cleaved in lysosomes by gamma-glutamyl hydrolase (GGH). GGH is reported to act as either ...

Medical images are regarded as important and sensitive data in the medical informatics systems. For transferring medical images over an insecure network, developing a secure encryption algorithm is necessary. Among the three main properties of security services ( i.e. , confidentiality, integrity, and availability), the confidentiality is the most essential feature for exchanging medical images...

Garg, Gentry and Halevi (GGH) described the first candidate multilinear maps using ideal lattices. However, Hu and Jia presented an efficient attack on GGH map, which breaks the GGH-based applications of multipartite key exchange (MPKE) and witness encryption (WE) based on the hardness of 3-exact cover problem. We describe a new construction of multilinear map using random matrix, which support...

BACKGROUND γ-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. In addition to genetic polymorphism and karyotypic abnormalities, methylation of CpG island 1 (CpG1) in the promoter region is found to modulate GGH activity by reducing GGH mRNA expression in acute...