objective: glut4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. the muscle is the major site of glut4 and cell line models, to explore glut4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. here, c2c12 cell line is evaluated for glut4 translocation from intracellular compartment into the cell membrane...

background: in diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. glut4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin. it remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not. objectives: the ob...

Objective: GLUT4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. The muscle is the major site of GLUT4 and cell line models, to explore GLUT4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. Here, C2C12 cell line is evaluated for GLUT4 translocation from intracellular compartment into the cell membrane...

We have described mouse models in which the expression levels of GLUT4 in skeletal muscle have been modified. GLUT4 null mice, which lack skeletal-muscle GLUT4, are insulin-resistant. In contrast, MLC-GLUT4 mice, which overexpress GLUT4 specifically in the skeletal muscle, exhibit an increase in insulin-sensitivity and glucose disposal. Restoring GLUT4 expression specifically in the skeletal mu...

Insulin stimulates glucose uptake by regulating translocation of the GLUT4 glucose transporter from intracellular compartments to the plasma membrane. In the absence of insulin GLUT4 is actively sequestered away from the general endosomes into GLUT4-specialized compartments, thereby controlling the amount of GLUT4 at the plasma membrane. Here, we investigated the role of the aminopeptidase IRAP...

OBJECTIVE We hypothesized that GLUT4 is a predominant facilitative glucose transporter in vascular smooth muscle cells (VSMCs), and GLUT4 is necessary for agonist-induced VSMC contraction. METHODS AND RESULTS Glucose deprivation and indinavir, a GLUT4 antagonist, were used to assess the role of GLUT4 and non-GLUT4 transporters in vascular reactivity. In isolated endothelium-denuded mouse aort...