There are anecdotal reports of early cerebrovascular complications occurring in patients with glucocorticoid-remediable aldosteronism (GRA). The issue has never been systematically evaluated. In this study, we retrospectively reviewed the International Registry for GRA to see if there was an association between cerebrovascular complications and GRA. We searched the records of 376 patients from ...

Background and objectives: Coumarins have potential anticancer effects. Ferulago macrocarpa (Fenzl) Boiss, is a perennial herb which has shown to have several dihydropyranocoumarins like grandivittin (GRA) and dihydrofuranocoumarins such as prantschimgin (PRA). Previously the antibacterial, cytotoxic and antioxidant effect of GRA and PRA have been reported. Understandi...

We propose the following principle to study pointed Hopf algebras, or more generally, Hopf algebras whose coradical is a Hopf subalgebra. Given such a Hopf algebra A, consider its coradical filtration and the associated graded coalgebra grA. Then grA is a graded Hopf algebra, since the coradical A0 of A is a Hopf subalgebra. In addition, there is a projection π : grA → A0; let R be the algebra ...

Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of most of these proteins still remains unknown. We targeted gene knockouts at ten GRA gene loci (GRA1-10) to investigate the cellular roles and esse...

We earlier showed that 18β-glycyrrhetinic acid (GRA), a pentacyclic triterpenoid from licorice root, could completely cure visceral leishmaniasis in BALB/c mouse model. This was associated with induction of nitric oxide and proinflammatory cytokine production through the up regulation of NF-κB. In the present study we tried to decipher the underlying cellular mechanisms of the curative effect o...

Granzyme A (GrA) and B (GrB) together with perforin are the main constituents of cytotoxic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. The cytotoxic proteins are released to deliver a lethal hit during contact between the CTL or NK cell and target cell. With the use of an enzyme-linked immunosorbent assay for antigenic levels, we showed in a recent study that plasm...

In recent years, the growing interest in the Intelligent Transportation Systems (ITS) has resulted in variety of peerreviewed publications. Significant results in this area have enabled many civilian and industry applications. As more and more vehicles are equipped with multiple network interfaces, how to efficient utilize the coexistence of Radio Access Technologies (RAT) such as WiFi, UMTS an...

Glucocorticoid-remediable aldosteronism (GRA) is a hereditary form of primary hyperaldosteronism that presents with hypokalemia and hypertension from childhood onward. GRA is characterized by the ectopic production of aldosterone in the cortisol-producing zona fasciculata under the regulation of adrenocorticotrophic hormone. Despite the early age of onset, no previous reports of pregnancy and G...

Chemotherapy-induced nausea and vomiting is a serious adverse side-effect of anthracycline-based chemotherapy regimens, in patients with breast cancer. A combination of three drugs, 5-hydroxytryptamine (5-HT3) receptor antagonist, aprepitant and dexamethasone, is recommended for antiemetic therapy. Palonosetron (PALO), a novel 5-HT3 receptor antagonist has been identified to be effective agains...