objective: type 2 diabetes (t2d) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. however, they were largely unsuccessful while applying to the more common forms of disease. by designing genome wi...

That’s interesting. Care to elaborate? Part of the problem in trying to make a movie about real animals is that they aren’t actors. You can write a script — and there was one — but the chimps didn’t always follow it! So, like a good field worker, one had to adapt as the film footage came in and the story line changed. In this day and age of global warming, disease pandemics, and the like, it’s ...

We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method that compares a pair of GWAS for similarity among the top SNP associations, top genes identified, gene functional clusters, and top biological pathways. We show that Joint GWA...

Panicle size has a high correlation with grain yield in rice. There is a bottleneck to identify the additional quantitative trait loci (QTL) for panicle size due to the conventional traits used for QTL mapping. To identify more genetic loci for panicle size, a panicle developmental trait (LNTB, the length from panicle neck-knot to the first primary branch in the rachis) related to panicle size ...

nce upon a time, medical genetics was a relaOtively straightforward business: one gene—one protein—one disease was sufficient to explain most inherited disease and was neatly in keeping with Gregor Mendel’s discovery of alleles with his famous peas. The concept remains a good starting point but the biology of life is somewhat more complex, and increasingly we have become impressed and perplexed...