Many bioactive molecules like recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed for mineralized bone grafts, for which proper scaffolds are necessary to successfully apply the bioactive molecules. In this study, we tested the osteogenic efficacy of rhBMP-2 produced in-house in combination with gelatin sponge as the scaffold carrier in a rabbit radial defect model. The...

Wastewater irrigation is a very important resource for heavy metal pollution in soil and then accumulation in vegetable crops. In this study, a polyethylenimine (PEI)-grafted gelatin sponge was prepared to effectively adsorb heavy metals during wastewater irrigation. Based on the strong water adsorption ability, wastewater remained in the PEI-grafted gelatin sponge for a sufficient time for the...

Bone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when using them in a clinical setting. In this study, we examined the effects of using a common clinical item, a hemostatic gelatin sponge, as a scaffold for bone tissue engineering. The use of...

OBJECTIVES To examine the usefulness of an absorbable hemostatic gelatin sponge for hemostasis after transrectal prostate needle biopsy. SUBJECTS AND METHODS The subjects comprised 278 participants who underwent transrectal prostate needle biopsy. They were randomly allocated to the gelatin sponge insertion group (group A: 148 participants) and to the non-insertion group (group B: 130 partici...

OBJECTIVE Arterial stenosis is a major obstacle for subsequent interventional procedures. We hypothesized that the stenosis is caused by gelatin sponge embolization and performed an experimental study in a rabbit renal model. MATERIALS AND METHODS A total of 24 rabbits were embolized with porcine gelatin sponge particles injected into the renal arteries. Four rabbits were sacrificed on 1 day,...

In vivo adipose tissue regeneration by preadipocytes was evaluated by combining them with collagen sponges with different biodegradabilities and gelatin microspheres incorporating basic fibroblast growth factor (bFGF) for the controlled release. The collagen sponge biodegradability was regulated from 1-4 weeks by changing the cross-linking conditions in collagen sponge preparation. The time pro...

Fracture nonunion and delayed union continue to pose challenges for orthopedic surgeons. In the present study, we combined HMGB1 gelatin sponges with MSC sheets to promote bone healing after surgical treatment of rat tibial fractures. The HMGB1 gelatin sponge scaffolds supported the expansion of mesenchymal stem cells (MSCs) and promoted the osteogenic differentiation of MSCs and MSC sheets. Le...

The objective of this study is to develop an osteoinductive scaffold which enables the controlled release of bone morphogenetic protein (BMP)-2. A biodegradable gelatin sponge incorporating 50 wt% of btricalcium phosphate (β-TCP) was fabricated to investigate the osteoinduction activity. The sponge prepared had an interconnected pore structure with an average pore size of 200 mm. The in vivo re...

Introduction: Socket grafting offers a predictable, simple way to conserve the buccolingual and mesiodistal dimensions of the future implant site, and various bone-grafting materials using various techniques have shown promising results. Aim: This case presentation describes the use of an absorbable gelatin sponge in the socket preservation procedure. Materials and Methods: A 47-year-old male p...