This Frontiers Research Topic, “Stem Cell Genetic Fidelity,” is the product of an attempt to develop a comprehensive integrative treatment of the historical progression of ideas and research advances on the topic of biological mechanisms of gene mutation control in tissue stem cells, with human tissues as a primary interest. In retrospect, this undertaking began with a somewhat ambitious goal f...

1. Abstract 2. Importance of retroviral genetic variation 3. Historic developments in understanding retroviral genetic variation and RT fidelity 4. Factors that influence retroviral mutation rates 4.1. Reverse transcription 4.2. Other viral proteins 4.3. Nucleotide pools, DNA repair, and mammalian DNA polymerases 4.4. RNA transcription 4.5. RNA modification 4.6. Antiviral nucleoside analogs 5. ...

The error rate of RNA-dependent RNA polymerases (RdRp) affects the mutation frequency in a population of viral RNAs. Using chikungunya virus (CHIKV), we describe a unique arbovirus fidelity variant with a single C483Y amino acid change in the nsP4 RdRp that increases replication fidelity and generates populations with reduced genetic diversity. In mosquitoes, high fidelity CHIKV presents lower ...

Molecular markers are efficient for assessing the genetic fidelity of various species of plants after in vitro culture. In this study, we evaluated the genetic fidelity and variability of micropropagated cassava plants (Manihot esculenta Crantz) using inter-simple sequence repeat markers. Twenty-two cassava accessions from the Embrapa Cassava & Fruits Germplasm Bank were used. For each accessio...

Digital Watermarking provides techniques to hide watermarks into digital content to protect it from illegal copy or reproduction. The prevalent techniques of digital watermarking in spatial domain cause the watermarked image to loose its image quality termed as Robustness and fidelity. Several techniques have been devised to optimize the Robustness and fidelity with given information content. R...

DNA replication fidelity plays fundamental role in faithful transmission of genetic material during cell division and during transfer of genetic material from parents to progeny. Replicative polymerases are the main guardian responsible for high replication fidelity of genomic DNA. DNA main replicative polymerases are also involved in many DNA repair processes. High fidelity of DNA replication ...

Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo. We have previously shown that norovirus intrahost genetic diversity also influences viral pathogenesis using the murine norovirus model, as increasing viral mutation frequency using a m...

We study an entangled two-mode coherent state within the framework of2×2-dimensional Hilbert space. We investigate the problem of quantum teleportation ofa superposition coherent state via an entangled coherent channel. By three differentmeasures with the titles ``minimum assured fidelity (MASF)”, ``average teleportationfidelity” and ``optimal fidelity (f)” we study the ...