Giant cell-rich osteosarcoma is an extremely rare variant of conventional osteosarcoma. It accounts for only 1%-3%. undifferentiated high-grade sarcoma with numerous osteoclast-like giant cells. also contains variable amount tumor osteoid. This article aims to present a case involving the right knee joint in young man.

A four-year-old male Persian cat was referred with three weeks history of progressive lameness due to a rigid osseous mass with 3.50×2.50×2.00 cm in dimensions in his left arm. In the histopathological evaluation of bone biopsy, two distinct populations of cells including multinucleated giant cells and oval cells which embedded in a fibro-osseous stroma and surrounded by lamellar bone trabecula...

BACKGROUND Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated. Previous studies have shown that the expression of CD31 w...

Giant cell-rich osteosarcoma of the jaw (JGCRO) is very rare but it diagnostically important because its poor prognosis compared to other variants osteosarcoma. We report a case recurrent JGCRO initially diagnosed as an ossifying fibroma. The clinical presentation, radiologic and histologic features intermediate outcome treatment are highlighted.

BACKGROUND Typical aneurysmal bone cysts (ABCs) are osteolytic, multicystic lesions with parietal sclerosis and blood-filled cysts. In rare instances, the cystic components may be completely absent. Such solid variants in ABC (s-ABC) exhibit a solid architecture; making the clinical, radiological, and histological differentiation from other solid bone tumors like osteosarcoma (especially giant ...

Giant cell rich osteosarcoma is a relatively unusual histological form of osteosarcoma, common lesion usually presenting in the long bones of the appendicular skeleton. The occurrence in the mandible is exceptional rare. Histologically, this tumor tends to be a highly anaplastic, pleomorphic tumor in which the tumor cells may be: plasmacytoid, fusiform, ovoid, small round cells, clear cells, mo...

Case Description and Clinical Findings- A seven-year-old male German shepherd dog was referred to Small Animal Clinic with severe lameness (non-weight-bearing) and considerable localized proximal right humerus swelling. Radiographic study revealed severe soft tissue swelling and pathologic fracture of proximal right humerus. Immediately, the right forelimb was removed surgically and once sample...

This study describes a case of giant cell osteosarcoma (GCO) localised on the right scapulae in six-year-old neutered male Scottish Fold cat. GCO is rare tumour domestic animals. also known as cell-rich osteosarcoma. Multinucleated cells and osteoid structures are observed GCO. The mass was 4.6 x 4.4 4.3 cm size very firm. Microscopically, fusiform spindle-shaped multinucleated were observed. T...

Aims At the histological level, the differential diagnosis of osteoblastic bone tumors is characterized by several problems that cannot be solved by conventional histological methods, including immunohistology. Differentiating aneurysmal bone cyst from telangiectatic osteosarcoma or giant cell tumor from giant cell-containing highly malignant osteosarcoma are only two examples reflecting the co...