amyloidosis includes a wide range of disorders characterized by deposition of amyloid in different organs and tissues. localized gingival enlargement due to accumulation of amyloid without involvement of other organs is a very rare condition. this article describes a 31-year-old male patient with amyloidosis involving only the periodontium of the anterior mandibular teeth with localized severe ...

Many terms have been used to describe gingival overgrowth. The expression gingival hyperplasia (“abnormal increase in the number of normal cells in a normal arrangement in an organ or tissue, which increase in volume”) and gingival hypertrophy (“enlargement or overgrowth of an organ or part due to an increase in size of its constituent cells”) have been also used, although gingival overgrowth i...

cyclosporine is a selective immunosuppressant that has a variety of applications in medical practice. like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. this review considers the pharmacokinetics, pharmacodynamics, and unwanted effects of cyclosporine, in particular the action of the drug on the gingival tissues. in addition, elucidates the current...

abstract background: although cyclosporine (csa) and calcium channel blockers (ccbs) parallel to each other may provoke gingival enlargement (ge), there are few considerations about combined effects of csa and ccbs on gingival tissues. objectives: this study aimed to determine prevalence of ge among renal transplant recipients and to compare its occurrence in patients who received only csa and ...

Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies ...

forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. no correlation was found between the scores of gingival overgrowth and both the age ...

57 INTRODUCTION Drug-induced gingival overgrowth is a disfiguring side effect of anticovulsants, calcineurin inhibitors, and calcium channel blocking agents. Phenytoin is an antiepileptic drug that acts on sodium channels in mammal cells. Clinically detectable gingival overgrowth occurs as the principal side-effect of phenytoin therapy in approximately half of the treated patients. Although the...

The purpose of this paper is to review the causes and describe the appearance of drug-induced gingival overgrowth, so that dental hygienists are better prepared to manage such patients. Gingival overgrowth is caused by three categories of drugs: anticonvulsants, immunosuppressants, and calcium channel blockers. Some authors suggest that the prevalence of gingival overgrowth induced by chronic m...