Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the prev...

Ginseng is now used worldwide as a traditional Oriental medicine. Ginsenosides, alsoknown as ginseng saponins, are responsible for most pharmacological efficacies of ginseng.This work aimed to assess the novel skin anti-photoaging potential of ginsenoside Re (Re), aprotopanaxatriol-type ginsenoside, by analyzing reactive oxygen species (ROS), pro-matrixmetalloproteinase-2 (proMMP-2) and -9 (pro...

Ginseng is now used worldwide as a traditional Oriental medicine. Ginsenosides, alsoknown as ginseng saponins, are responsible for most pharmacological efficacies of ginseng.This work aimed to assess the novel skin anti-photoaging potential of ginsenoside Re (Re), aprotopanaxatriol-type ginsenoside, by analyzing reactive oxygen species (ROS), pro-matrixmetalloproteinase-2 (proMMP-2) and -9 (pro...

BACKGROUND Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug-nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect o...

The protective effect of ginsenoside Re, isolated from ginseng berry, against acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (C48/80). Ginsenoside Re (20 mg/kg or 100 mg/kg) was orally administered 0.5 h prior to C48/80 treatment. Ginsenoside Re dose-dependently prevented gastric mucosal lesion development 3 h after C48/80 treatment....

Araliaceae) is frequently used as a traditional medicine, taken orally, in China, Korea, Japan and other Asian countries. The major components of ginseng, the ginsenosides, are glycosides that contain an aglycone with a dammarane skeleton. These ginsenosides have been reported to show various biological activities, including immunomodulatory effect, anti-inflammatory activity and antitumor effe...

Seven new dammarane-type triterpenoid saponins, chikusetsusaponin FK1 (1), chikusetsusaponin FK2 (2), chikusetsusaponin FK3 (3), chikusetsusaponin FK4 (4), chikusetsusaponin FK5 (5), chikusetsusaponin FK6 (6), and chikusetsusaponin FK7 (7), and eleven known triterpenoid saponins, ginsenoside Rb3 (9), ginsenoside Rc (10), chikusetsusaponin VI (11), ginsenoside Re (12), ginsenoside Rg1 (13), pseu...

Objective—The umbilical cord is a critical pathway between mothers and fetuses, and regulations of umbilical vessel tension are important for fetal growth. Shengmai is an herbal medicine being used in treatments of cardiovascular diseases. However, effects of Shengmai on human blood vessels and related pharmacological mechanisms are unclear. Methods—This study investigated the effects of relate...

OBJECTIVE Ginseng and its active component, ginsenoside Re, are popular herbal products that are advocated for treatment of diabetes. The purpose of this study was to determine whether ginseng or ginsenoside Re improves β-cell function and insulin sensitivity (IS) in insulin-resistant subjects. RESEARCH DESIGN AND METHODS Overweight or obese subjects (BMI = 34 ± 1 kg/m²) with impaired glucose...

The berry of Panax ginseng significantly inhibited the histamine releases at the concentration of 30 μg/mL (p<0.05) and 10 μg/mL (p<0.01). The ginsenoside Re from ginseng berry was found out to have a potent effect in the experiment of histamin and cytokine release.