stereologic methods are used to abtain quantitative information about 3-dimensional structures from histologic sections. the aim of the present study was using new and unbiased stereologic techniques to investigate changes in volume and number of glomeruli after chronic lead acetate intoxication both quantitatively and in 3-dimensional spaces.lead is one of the heavy metals that has adverse eff...

objective(s) oxidative stress plays an important role in diabetic nephropathy pathogenesis. rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. material and methods forty male rats were uninephrectomized from the left flank.the rats were divided in four groups randomly; group one as control, group two diabetic untreatment, g...

To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched genes that emerged from these different sources and then used this to construct a predicted protein-protein interacti...

Reorganization of the cerebellar glomerulus, the main synaptic complex within the granule cell layer, was investigated using quantitative morphological techniques. All afferents to the cerebellar cortex, including mossy-fibers, were surgically destroyed by undercutting the cerebellar vermis. Fifteen days after the operation, which resulted in the removal of the main excitatory afferent to the g...

Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA-like immunoreactivity specifically labeled somata, axons, and terminals of ze...

Suatu kondisi metabolik yang disebut diabetes melitus (DM) diakibatkan oleh ketidakmampuan untuk mengeluarkan insulin. Tujuan penelitian ini adalah mengetahui pengaruh pemberian ekstrak etanol daun karanda (Carissa carandas L.) terhadap morfologi dan histologi ginjal tikus diabetes. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan enam kelompok variasi yaitu glibenklamid, kontrol norm...

Glomerulus segmentation in kidney tissue segments is a crucial nephropathology process used to diagnose renal diseases effectively. This study proposes novel and robust application of MLP (Multi-Layer Perceptron) based architectures for the glomeruli PAS (Periodic AcidSchiff) stained whole images effective diagnosis diseases. For challenge, proposed unique solution uses MLP-UNet Perceptron U-Ne...