introduction: the fate of xenobiotics that is present, increasing day by day. the increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. methods: the present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by panax ginseng ...

resistance of the weanling rat to acetaminophen (ap ap)-induced hepatotoxicity is manifested with regard to a surge in apap-glutathione (osh) conjugate formation in the liver [allameh et al. mech aging dev 95(1997)71]. the present study was conducted to assess the role of this detoxification pathway in apapinduced lipid per6xidationin the liver. lipid peroxidation measured as thiobarbituric aci...

helicobacter pylori infection leads to different clinical and pathological outcomes in humans, including chronic gastritis and gastric neoplasia. it has been demonstrated that oxidative stress associated with inflammation plays an important role in gastric carcinogenesis. to evaluate the oxidative stress in h. pylori infection we studied the gastric juice levels of nitric oxide and the activiti...

objective: to determine the relationship between serum glutathione peroxidase and febrile seizure. materials & methods:   in this case-control study, 43 children with simple febrile seizure (case group) were compared with 43 febrile children without seizure (control group) in terms of serum glutathione peroxidase level. serum glutathione peroxidase levels were measured by elisa method. the resu...

one of the major classes of ionotropic glutamate receptors is the class of n-methyl-d-aspartate receptors (nmdars). receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to excitotoxicity and neuronal death. in...

background: over the past few years, the rapid use of high frequency electromagnetic fields like mobile phones has raised global concerns about the negative health effects of its use. adaptive response is the ability of a cell or tissue to better resist stress damage by prior exposure to a lesser amount of stress. this study aimed to assess whether radiofrequency radiation can induce adaptive r...

occupational exposure to toluene is associated with development and progression of renal failure. however, the cellular mechanisms by which these agents cause renal dysfunction and injury remain elusive. the present study investigates the effect of toluene on animal model (rat) kidney to present a broader understanding of the mechanism by which toluene causes renal injury. adult male rats recei...

background: glutathione (gsh) is a non-protein thiol compound, which plays an important role in the response to oxidative stress and nutritional stress. the aim of this study was to isolate indigenous s. cerevisiae strains capable of effectively produce gsh. methods: one hundred-twenty sweet fruit samples were collected. the strains were isolated on yeast glucose chloramphenicol (ygc) agar medi...

objective: it is well known that diabetes is one of the main health challenges. according to the evidence presented in recent years by investigators, serum uric acid has emerged as a possible risk factor for diabetes mellitus. the aim of the present study was to compare the mean serum uric acid and the antioxidant activity of glutathione levels in patients with diabetes and the control group. m...

simultaneous exposure of highly-used chemical and physical agents are expected to happen in many occupations. in the present study the impact of simultaneous exposure to noise and formaldehyde on oxidative stress in blood and liver tissue of rat was investigated. animal study was conducted in the school of public health, shahid beheshti university of medical scineces, tehran, iran in 2013. a to...