This exceptionally well done book organizes the proceedings of the International Symposium on Gonadotropins held at the New York Hospital Bicentennial Celebration in 1971 into 58 essays which survey the chemistry and physiology of FSH, LH, and prolactin. The book's major attribute is the special care taken to present gonadotropin research in perspective. Thus, the first essay, if not all of the...

Five years after the demonstration of anterior pituitary dominance over the gonads by the Smiths and Aschheim and Zondek, Moore and Price asserted the classic principle of the reciprocal "feedback" relationship between the secretions of these organs. Three decades later continued investigation of this interdependence has culminated in two major advances in clinical medicine: steroid inhibition ...

Gonadotropins secreting pituitary tumors tend to present as sellar mass with hypogonadism. Biologically active LH secretion by these tumors resulting in elevated testosterone is extremely rare. We report a case of a 48-year-old male patient who presented with giant pituitary tumor, elevated testosterone, and elevated levels of gonadotropins. Surgical resection of the tumor resulted in normaliza...

We show here that elevated levels of gonadotropins (luteinizing hormone and follicle stimulating hormone), as found in menopause or after ovariectomy, promote growth of human ovarian carcinoma by induction of tumor angiogenesis. Human epithelial ovarian cancer tumors progressed faster in ovariectomized mice. This induced growth could be attributed to the elevated levels of gonadotropins associa...

background: despite the large number of papers published on the efficiency of different exogenous gonadotropins, no confirmed protocol exists. therefore, the aim of the present study was to compare the efficacy of 4 exogenous gonadotropins in ivf/icsi cycles. methods: this study, performed from january 2014 to may 2014, recruited 160 women referred to ghadir mother and child hospital and dena h...

Article history: Received 23 October 2007 Received in revised form 21 February 2008 Accepted 25 February 2008 Available online xxxx EC TE D PR Reproductive hormones have been demonstrated tomodulate both gapand tight-junctionprotein expression in reproductive tissues and endometrium,however the effects of changes in reproductive hormoneson the selective permeability of the blood-brain barrier (...

Reproductive hormones have been demonstrated to modulate both gap and tight junction protein expression in the ovary and other reproductive tissues, however the effects of changes in reproductive hormones on the selective permeability of the blood-brain barrier (BBB) remain unclear. Age-related declines in BBB integrity correlate with the loss of serum sex steroids and increase in gonadotropins...

Inhibin B is a gonadal dimeric polypeptide hormone that regulates synthesis and secretion of follicle stimulating hormone (FSH) in a negative feedback loop. The aim of the present study was to determine changes in serum inhibin B, gonadotropins and testosterone concentrations during childhood and puberty in males. We studied the relationship between circulating inhibin B, gonadotropins and test...

Gonadotropin therapy plays an integral role in ovarian stimulation for infertility treatments. Efforts have been made over the last century to improve gonadotropin preparations. Undoubtedly, current gonadotropins have better quality and safety profiles as well as clinical efficacy than earlier ones. A major achievement has been introducing recombinant technology in the manufacturing processes f...

Gonadotropins (FSH and LH) are detectable in ovarian tumor fluid, suggesting a possible role for gonadotropins in ovarian carcinogenesis and progression. However, the molecular mechanisms behind the role of gonadotropins in ovarian cancer development are unknown. Cyclooxygenase (COX) enzymes, COX-1 and COX-2, play crucial roles in the pathogenesis of human malignancies. The purpose of the curre...