According to ayurvedic texts shodhan vidhi is an important process which enhances the biological activity of a compound and reduces the toxicity at the same time. Before incorporating into formulations, guggul is processed using Shodhan vidhi involving different shodhan dravyas like gulvel, gomutra, triphala, dashmul. We have evaluated the antispasmodic activity of guggul on ileum of guinea pig...

Objective of this study was to evaluate Guggul extract for the treatment of Alzheimer’s disease using scopolamine induced amnesia in mice on Morris water maze. Guggul extract (50mg/kg) was administered orally for fifteen successive days followed by Scopolamine (0.4 mg/kg i.p.) from 15 th to 18 th day in mice. Morris water maze was employed to evaluate learning and memory using parameter like Es...

Gum guggul and its constituents are increasingly being used as dietary supplements. Biological effects have been demonstrated on lipid metabolism, thyroid hormone homeostatsis, female reproductive tissues, and endogenous nuclear hormone receptors. Gum guggul is the oleoresin of Commiphora mukul, a plant that is native to India, and its extracts include compounds known for their hypolipidemic pr...

Oleogum resin (known as guggul) from the guggul tree, Commiphora mukul, found in India, Bangladesh, and Pakistan, has been used to treat various diseases including hyper-cholesterolemia, atherosclerosis, rheumatism, and obesity over several thousands of years. Guggulsterone isolated from guggul has been identified as the bioactive constituent responsible for guggul's therapeutic effects. Since ...

Guggulosomes prepared using guggul by bath sonication and trituration methods were studied for optical microscopy, in vitro release profile, entrapment efficiency of drugs and anti-inflammatory activity. Average particle size determined was between 0.1 μm to 0.2 μm. Guggulosomes sustained the drug release for a period of 9 hrs and more in bath sonification method. Ibuprofen loaded guggulosomes ...

CONTEXT Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. OBJECTIVE Aceclofenac nanovesicles were made using guggul lipid for formulating stable transdermal formulation. MATERIALS AND METHODS Guggul lipid was formulated into vesicles along with cholesterol and dice...

The present study reports physicochemical characterization and antioxidant activity of essential oils extracted from guggul (Commiphora wightii) exudates collected from different places in Madhya Pradesh, India. The guggul exudates were hydrodistilled for 3-4 h in Clevenger apparatus. The oil obtained was dried over anhydrous Na2SO4 and stored at 4° until testing. Before extraction of oils from...

this experiment was conducted to determine the effects of the oral consumption of guggulplant resin on the performance and humoral immunity response of broiler chicks. for doing this experiment, 320 one-day old chicks of the cobb 500 strains, in a completely randomized design with 4 treatments and 4 replicates were used. experimental diets include: control diet (without the guggul), control die...

Herbal preparations have long been used for treatment of variety of diseases. However, a systematic and scientific evaluation of their effects and mechanisms of action have been lacking, although it is believed that synergistic complementation of the effects of the multiple chemical components in these preparations would be playing crucial regulatory roles in the different metabolic pathways wh...

Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul lipid as major lipid component and analyzed for physical parameters, permeation profile, and anti-inflammatory activity. The SLNs were prepared using melt-emulsion sonication/low temperature-solidification method and characterized for physical parameters, in vitro drug release, and accelerated stability studi...