نتایج جستجو برای: HAS2

تعداد نتایج: 284  

2016
Jiying Liu Fei Tu Wang Yao Xinyu Li Zhuang Xie Honglin Liu Qifa Li Zengxiang Pan

The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly understood. Here, we report that miR-26b regulates porcine GC (pGC) apoptosis...

Journal: :The American journal of pathology 2006
Melanie A Simpson

Aggressive cells in prostate cancer secrete extracellular hyaluronan (HA) as a result of up-regulated HA synthase enzymes HAS2 and HAS3. Combined detection of HA and the HA processing hyaluronidase enzyme Hyal1 in prostate tumors correlates with poor outcome. HA oligomers produced by hyaluronidases are potent angiogenic stimuli. We investigated the respective roles of HAS2 and Hyal1 using 22Rv1...

Journal: :International journal of clinical and experimental pathology 2015
Peng Li Tingxiu Xiang Hongzhong Li Qianqian Li Bing Yang Jing Huang Xiang Zhang Yuan Shi Jinxiang Tan Guosheng Ren

Extracellular matrix (ECM) is closely correlated with the malignant behavior of breast cancer cells. Hyaluronan (HA) is one of the main components of ECM, and actively regulates cell adhesion, migration and proliferation by interacting with specific cell surface receptors such as CD44 and RHAMM. HA synthase 2 (HAS2) catalyzes the synthesis of HA, but its role in breast tumorigenesis remains unc...

Journal: :Journal of cell science 2002
Kirsi Rilla Mikko J Lammi Reijo Sironen Kari Törrönen Merja Luukkonen Vincent C Hascall Ronald J Midura Mika Hyttinen Jukka Pelkonen Markku Tammi Raija Tammi

Hyaluronan is a major component of the epidermal extracellular matrix, is actively synthesized by keratinocytes and shows fast matrix turnover in the stratified epithelium. We probed the importance of hyaluronan synthesis in keratinocytes by establishing cell lines carrying the exogenous hyaluronan synthase 2 (Has2) gene in sense and antisense orientations to increase and decrease their hyaluro...

Journal: :The Journal of clinical investigation 2000
T D Camenisch A P Spicer T Brehm-Gibson J Biesterfeldt M L Augustine A Calabro S Kubalak S E Klewer J A McDonald

We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(-/-) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5-10). Heart explants from Has2(-/-) embryos lack the characteristic transformation of cardiac endothelial cells into ...

2014
Xiaomei Zhu Xiaopeng Deng Guangying Huang Jing Wang Jingwen Yang Si Chen Xu Ma Binbin Wang

As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and vascular defects. To clarify the potential association of the mutation in HAS2 with the development of congenital heart disease (CHD), in this...

2016
Ziwen Zhang Detao Tao Ping Zhang Xue Liu Yuchao Zhang Jie Cheng Hua Yuan Laikui Liu Hongbing Jiang

BACKGROUND Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix. However, little is known about the role of HAS from CAFs in this process. This study aimed to determine the role of hyaluronan synthase 2 (HAS2) from CAFs in the progre...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Sunny Guin Yuanbin Ru Neeraj Agarwal Carolyn R Lew Charles Owens Giacomo P Comi Dan Theodorescu

PURPOSE We demonstrated that amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) is a tumor growth suppressor and prognostic marker in human bladder cancer. Here we determine how AGL loss enhances tumor growth, hoping to find therapeutically tractable targets/pathways that could be used in patients with low AGL-expressing tumors. EXPERIMENTAL DESIGN We transcriptionally profiled blad...

Journal: :The Biochemical journal 2000
W Zhang C E Watson C Liu K J Williams V P Werth

Glucocorticoid (GC) administration induces atrophy of skin, bone, and other organs, partly by reducing tissue content of glycosaminoglycans, particularly hyaluronic acid (HA). We took advantage of the recent cloning of the three human hyaluronan synthase (HAS) enzymes (HAS1, HAS2 and HAS3), to explore the molecular mechanisms of this side effect. Northern and slot blots performed on RNA extract...

Journal: :The Journal of biological chemistry 2004
Jamie Monslow John D Williams Carol A Guy Iain K Price Kathrine J Craig Hywel J Williams Nigel M Williams John Martin Sharon L Coleman Nicholas Topley Andrew P Spicer Paul R Buckland Malcolm Davies Timothy Bowen

Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. The regulation of HA synthesis has been implicated in a variety of extracellular matrix-mediated and pathological processes, including renal fibrosis. We have recently described the genomic structures of each of the hum...

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