نتایج جستجو برای: HIN

تعداد نتایج: 1386  

Journal: :Mechanisms of Development 2002
Dale Porter Jaana Lahti-Domenici Marisa Torres-Arzayus Lynda Chin Kornelia Polyak

We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression...

Journal: :Bibliothek Forschung und Praxis 2014

Journal: :Molecular cancer research : MCR 2004
Ian Krop Audrey Player Ana Tablante Michele Taylor-Parker Jaana Lahti-Domenici Junya Fukuoka Surinder K Batra Nickolas Papadopoulos William G Richards David J Sugarbaker Renee L Wright Judy Shim Thomas A Stamey William R Sellers Massimo Loda Matthew Meyerson Ralph Hruban Jin Jen Kornelia Polyak

HIN-1 (high in normal-1) is a candidate tumor suppressor identified as a gene silenced by methylation in the majority of breast carcinomas. HIN-1 is highly expressed in the mammary gland, trachea, lung, prostate, pancreas, and salivary gland, and in the lung, its expression is primarily restricted to bronchial epithelial cells. In this report, we show that, correlating with the secretory nature...

Journal: :Encyclopédie berbère 2000

Journal: :Cancer research 2003
Ian Krop Paula Maguire Jaana Lahti-Domenici Gabriela Lodeiro Andrea Richardson Hrefna Kristin Johannsdottir Heli Nevanlinna Ake Borg Rebecca Gelman Rosa Björk Barkardottir Annika Lindblom Kornelia Polyak

We recently identified a candidate tumor suppressor gene, HIN-1, that is silenced due to methylation in the majority of sporadic breast carcinomas and is localized to 5q33-qter, an area frequently lost in BRCA1 tumors and thought to harbor a BRCA1 modifier gene. To establish whether germ-line mutations in HIN-1 may influence breast cancer risk, we sequenced the HIN-1 coding region in 10 familia...

Journal: :Cancer research 2005
Ian Krop Michele Taylor Parker Noga Bloushtain-Qimron Dale Porter Rebecca Gelman Hidefumi Sasaki Matthew Maurer Mary Beth Terry Ramon Parsons Kornelia Polyak

The HIN-1 gene encoding a small, secreted protein is silenced due to methylation in a substantial fraction of breast, prostate, lung, and pancreatic carcinomas, suggesting a potential tumor suppressor function. The receptor of HIN-1 is unknown, but ligand-binding studies indicate the presence of high-affinity cell surface HIN-1 binding on epithelial cells. Here, we report that HIN-1 is a potent...

Journal: :Genes & development 1988
K T Hughes P Youderian M I Simon

The bacteriophage P22-based challenge phase selection was used to characterize the binding of Salmonella Hin recombinase to the wild-type hixL and hixR recombination sites, as well as to mutant and synthetic hix sequences in vivo. Hin recombinase binds to the hixL or hixR recombination sites and represses transcription from an upstream promoter in the challenge phage system. Hin-mediated repres...

2013
Meghan M McLean Yong Chang Gautam Dhar John K Heiss Reid C Johnson

Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing two binding sites for the protein Fis. Two Hin dimers bound to specific recombination sites associate with the Fis-bound enhancer by DNA loopi...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Thian Sze Wong Dora Lai-Wen Kwong Jonathan Shun-Tong Sham Sai Wah Tsao William Ignace Wei Yok Lam Kwong Anthony Po-Wing Yuen

PURPOSE The methylation of high-in-normal-1 (HIN-1) gene promoter in undifferentiated nasopharyngeal carcinoma (NPC) is studied. EXPERIMENTAL DESIGN The methylation status of HIN-1 in NPC cell lines, primary NPC, paired nasopharyngeal swabs, paired throat-rinsing fluid, and paired peripheral blood was assessed by methylation-specific PCR assay. The relationship between HIN-1 promoter methylat...

2009
Robert D Gregg

l −− > leg length M −− > hip mass m −− > midleg mass gamma −− > slope angle Beta −− > potential shaping angle Hdifference between passive slope angle and actual slope gammaL c −− > Lateral control proportional constant Hin functional conserved quantityL d −− > Lateral control bias constant Hin functional conserved quantityL r −− > Yaw control proportional constant Hin functional conserved quant...

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