conclusions expression of hmgb1 and c-iap2 proteins was associated with hcc development and progression, and the expression of hmgb1 and c-iap2 proteins in hcc were significantly associated with each other. additionally, these proteins may show promise as biomarkers to predict hcc progression. background hepatocellular carcinoma (hcc) is one of the most important health problems in china. objec...

objective(s): high mobility group box1 (hmgb1) is a nonhistone, dna-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. the aim of this study was to explore whether hmgb1 stimulation can up-regulate the expression of toll-like receptor 2 (tlr2) and toll-like receptor 4 (tlr4) on macrophages from p...

Objective(s): High Mobility Group Box1 (HMGB1) is a nonhistone, DNA-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. The aim of this study was to explore whether HMGB1 stimulation can up-regulate the expression of Toll-like Receptor 2 (TLR2) and Toll-like Receptor 4 (TLR4) on macrophages from p...

one of the inflammatory mediators which is secreted by inflammatory cells is high-mobility group protein b1 (hmgb1). interaction of hmgb1 and toll-like receptors (tlrs) leads to increased production of inflammatory cytokines. on the other hand, it was shown that triggering receptor expressed on myeloid cells (trem-1) also can be activated by tlrs, and its soluble form (strem-1) can be formed by...

Background Earlier it was believed that uterine fluid (uf) or secretions are not relevant after the embryo implantation in humans. However, recent reports suggest that uterine secretions continue to play important role till the first trimester of human pregnancy. Evidences also suggest that uf mirrors endometrial functions or dysfunctions. Considering the relevance of uf in endometrial function...

INTRODUCTION High Mobility Group Box 1 (HMGB1) is a nuclear non-histone protein. HMGB1, which is secreted by inflammatory cells and passively released from apoptotic and necrotic cells, may act as a pro-inflammatory mediator. As apoptotic cells accumulate in systemic lupus erythematosus (SLE), HMGB1 levels might be increased in SLE. HMGB1 may also serve as an autoantigen, leading to the product...

AIMS High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. HMGB1 binds to DNA, facilitating numerous nuclear functions including maintenance of genome stability, transcription, and repair. However, little is known about the effects of nuclear HMGB1 on cardiac hypertrophy and heart failure. The ...

Highly expressed high mobility group box-1 protein (HMGB1) promotes tumor metastasis. Whether HMGB1 participates in breast cancer cell activation of fibroblasts is unknown. The culture medium 6 lines with different migration potential, and overexpression or knockdown was used to induce fibroblast activation, collagen α-SMA expression were measured. We evaluated the potential MDA-MB-231 cells tr...

BACKGROUND As an extracellularly released mediator, high-mobility group box 1 (HMGB1) initiates sterile inflammation following severe trauma. Serum HMGB1 levels correlate well with acute traumatic coagulopathy (ATC) in trauma patients, which is independently associated with higher mortality. We investigated the involvement of HMGB1 in ATC through blocking extracellular HMGB1. MATERIAL AND METHO...