Background: The HU linearity is an essential parameter in a quantitative imaging and the treatment planning systems of radiotherapy. Objective: This study aims to evaluate the linearity of Hounsfield unit (HU) in applying the adaptive iterative dose reduction (AIDR) on CT scanner and its comparison to the filtered back-projection (FBP).Material and Methods: In this experimental phan...

The American College of Radiology (ACR) Computed Tomography (CT) Accreditation Program requires submission of phantom scans acquired with the ACR accreditation phantom. There is a known issue with some wide-beam scanners in which the Hounsfield unit (HU) value of water may be correct when using the scanner manufacturer's phantom, but will be out of range in some scan modes when scanning the acc...

Background: Methods for segmentation, i.e., Full-segmentation (FS) and Segmentation-rotation (SR), are proposed maintaining Computed Tomography (CT) number linearity. However, their effectiveness has not yet been tested against noise.Objective: This study aimed to evaluate the influence of noise on accuracy CT linearity FS SR methods American College Radiology (ACR) computational phantoms.Mater...

Introduction: The performance of computed tomography is routinely checked using phantoms, which are known as important diagnostic imaging tools. Depending upon the aim of the study, different phantoms are designed, while trying to satisfy certain levels of diversities in their application. Material and Methods: The present study describes the...

Sickle cell anemia (SCA) is a recessively inherited disease characterized by chronic hemolytic anemia, chronic inflammation, and acute episodes of hemolysis. Hydroxyurea (HU) is widely used to increase the levels of fetal hemoglobin (HbF). The objective of this study was to standardize and validate a method for the quantification of HU in human plasma by using ultra high performance liquid chro...

Identifying meaningful signal buried in noise is a problem of interest arising in diverse scenarios of datadriven modeling. We present here a theoretical framework for exploiting intrinsic geometry in data that resists noise corruption, and might be identifiable under severe obfuscation. Our approach is based on uncovering a valid complete inner product on the space of ergodic stationary finite...

Background: Hydroxyurea (HU) is a well known chemotherapeutic agent that has been used largely for various myeloproliferative diseases over the past 20 years. In β-thalassemia, the effect of HU is much less clear and remains controversial. This study was undertaken to describe the hematologic and clinical responses of thalassemia major and intermediate patients to HU treatment during 2 years. M...

background: hydroxyurea (hu) is a well known chemotherapeutic agent that has been used largely for various myeloproliferative diseases over the past 20 years. in β-thalassemia, the effect of hu is much less clear and remains controversial. this study was undertaken to describe the hematologic and clinical responses of thalassemia major and intermediate patients to hu treatment during 2 years. m...

Introduction: In radiotherapy treatment planning system (TPS), basic input is the data from computed tomography (CT) scan, which takes into account the effect of inhomogeneities in dose calculations. Measurement of CT numbers may be affected by scanner-specific parameters. Therefore, it is important to verify the effect of different CT scanning protocols on Hounsfield unit (HU) and its impact o...

Cancer is a fatal disease and relatively widespread in the world; Breast cancer is the most prevalent cancer among women. Hydroxyurea (HU) is a chemotherapy drug for the cure of cancer different types in patients, for example breast cancer, but has several defects, for to remove these problems in this study a nanoliposome (NL) suspension for Hydroxyurea (HU) delivery in breast cancer cell thera...