In this research at the first Promethazine drug and its fullerene derivative were optimized. NMR calculations for the complexes were carried out at the B3LYP/6-31G*quantum chemistry level. Promethazine is not used as an antihistaminic drug for anyone. In the pharmaceutical composition of promethazine (RS) - N, N-dimethyl-1- (10H-Phenothaiazin-10 yl) -propen-2-amino, two aromatic rings In this s...

To study the effect of calcium ion on aromatization of an androgenic precursor to estradiol by the placenta, cultured term trophoblasts were used as a model system. Secretion of estradiol into the culture medium was regarded as indicating aromatization, since cells cultured with no androgenic precursors produced only insignificant amounts of estradiol. EGTA, verapamil and ionophore A23187 inhib...

The aromatization of androstenedione is inhibited in the presence of aminoglutethimide, diethylaminoethyl-2,2-diphenyl valerate HCl (SKF 525-A), and 1W3 M KCN, but not carbon monoxide or metyrapone. The role of cytochrome P-450 in this reaction could not, therefore, be unequivocally established by inhibition studies. However, it was determined that steroid binding to placental microsomal cytoch...

In spite of the fact that musical hallucination have a significant impact on patients' lives, they have received very little attention of experts. Some researchers agree on a combination of peripheral and central dysfunctions as the mechanism that causes hallucination. The most accepted physiopathology of musical hallucination associated to hearing loss (caused by cochlear lesion, cochlear nerv...

The aromatization reaction of liquefied petroleum gas has been studied by using three liquefied petroleum gases as raw material and LBO-A as catalyst, and four lump kinetics models networks have been put up on the basis of lump theory and the aromatization reaction mechanism. In the network the aromatization reaction species was firstly lumped into C 4 , propylene, low molecule hydrocarbon, liq...

Aromatization of testosterone in Leydig cells purified from mature rat testes was assessed. Leydig cells incubated for 4 hr with increasing concentrations of [3H]testosterone. At saturating concentrations of testosterone, human chorionic gonadotropin (hCG) acutely stimulated aromatization. This stimulation was first observed at 1 hr, an 8-fold increase being found during a 4-hr incubation. The ...

The significance of in vitro aromatization of [7 alpha-3H]testosterone to estradiol by human breast cancer has been investigated by correlation with (a) estrogen receptor activity and (b) clinical response to endocrine therapy. Evidence for estradiol synthesis was obtained in 66 and estrogen receptor activity in 81 of 110 tumors. Whereas most estrogen receptor-positive tumors synthesized estrad...

The rapid and sensitive assay of lfl,2@3H-androgen aromatization by measurement of ‘HZ0 release (Thompson, E. A., Jr., and Siiteri, P. K. (1974) J. Biol. Chem. 249,5364-5372) has been analyzed to determine its applicability to initial rate studies. It was found that aromatization is the sole reaction catalyzed by lyophilized placental microsomes that causes a loss of tritium from position 1 or ...

Although rumination has been proposed to play an important role in the creation of hallucinations, direct empirical tests of this proposal have not yet been performed. Employing a distinction between ruminative and reflective self-consciousness, we set out to test a new model of the relations among rumination, reflection, intrusive thoughts, thought suppression, social anxiety, and hallucinatio...