The relationships between lipophilicity and unspecific biological properties, such as narcotic, fungicidal, bactericidal, hemolytic and toxiccity properties have been known ever since the turn of the century. Research publications of Free Wilson method [1] and that of Hansch analysis [2] during 1964 served as the milestones in development of quantitative structure-activity relationships (QSAR)....

Accepted 27 December 2006 Revised 23 March 2006 Received 9 September 2005 Indian J. Pharm. Sci., 2006, 68 (6): 826-829 3. Bhattacharya, D.K., Lecomte, M., Rieke, C.J., Garavito, R.M. and Smith, W.J., J. Biol. Chem., 1996, 271, 2179. 4. Rieke, C.J., Mulichak, A.M., Garvitto, R.M. and Smith, W.L., J. Biol. Chem., 1999, 274, 1709. 5. Kalgutkar, A.S., Marnett, A.B., Crews, B.C., Remmel, R.P. and Ma...

a series of angiotensin ii (a ii) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to qsar analysis using hansch and fujita-ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. several qsar model were obtained using stepwise regression analysis. two models from both the method...

In this issue of Journal of Computer-Aided Molecular Design we pay tribute to Corwin Hansch, who died on May 8 at the age of 91. Professor Hansch (Corwin to almost everyone, at his insistence) was a giant in our field, the ‘father’ of QSAR, and the vanguard of rational drug design. Thanks to his long-time colleague and coworker, Cynthia Selassie, also of Pomona College, we are, with sadness, pu...

Activity of 2-alkylthio-6-aminobenzothiazoles and their 6-A/-substituted derivatives (3-(2-alkylthio6-benzothiazolylaminomethyl)-2-benzothiazolinethiones and 3-(2-alkylthio-6-benzothiazolylaminomethyl)-6-bromo-2-benzothiazolinones) concerning photosynthesis inhibition in algae Chlorella vulgaris and in spinach chloroplasts has been correlated with lipophilicity and dipóle moments of the effecto...