The present investigations evaluated the antioxidant and antidiabetic activity of Helicteres isora (L.) fruits belonging to the family Sterculiaceae. The hot water extract of Helicteres isora fruits was prepared and screened for its in vitro antioxidant activity using 1,1-diphenyl,2-picryl hydrazyl assay, ss-carotene-linoleate model and microsomal lipid peroxidation or thiobarbituric acid react...

The present investigation was carried out to evaluate the protective role of Helicteres isora plant extract on glycoprotein metabolism in streptozotocin (STZ) induced type 2 diabetic rats. Helicteres isora plant extract was administered orally (200 mg/kg body weight) for 45 days to normal and diabetic rats. The effects of Helicteres isora plant extract on plasma and tissue glycoproteins (hexose...

BACKGROUND AND OBJECTIVES Herbal medicines have good curative effect on certain diseases especially for diabetes mellitus which needs continuous medication throughout the life. Present day allopathic medicines are costlier and having more side effects which could cause severe damages to the vital organs. Hence, finding a suitable herbal medicine for diabetes mellitus is very important in the cu...

Antibacterial activities of aqueous, acetone, ethanol and methanol extracts of fruits of Helicteres isora (Mororphali) were studied. The fruit aqueous extracts of H. isora showed prominent antibacterial activities against E. coli, Staphylococcus epidermidis, Salmonella typhimurium and Proteus vulgaris; moderate activity against Enterobacter aerogenes, Staphylococcus aureus, Salmonella typhi and...

Diabetes mellitus is one of the major disease currently affecting an estimated 143 million people worldwide and the number is growing rapidly. Now a day, as there is a renewed interest in the traditionally used herbal drugs, the present study was aimed to screen the identified constituents of Helicteres isora for determining the potent constituent with antidiabetic activity using insilico appro...

The effect of hot water extract of fruits of Helicteres isora on glucose uptake was studied in rodent skeletal muscle cells (L-6 cells) involved in glucose utilization. H. isora is an antidiabetic medicinal plant being used in Indian traditional medicine. Hot water extracts were analysed for glucose uptake activity and found to be significantly active at 200 mug/ml dose comparable with insulin ...

In present study, in vitro α-amylase inhibition and streptozotocin-induced oxidative stress were used to evaluate hypoglycemic effects of Helicteres isora (sterculiaceae). Antidiabetic treatment with of H. isora extract (100 mg/kg and 250 mg/kg body weight) for three weeks showed significant reduction in thiobarbituriuc acid reactive substances (TBRAS) and glutathione reductase (GSH-R) in both ...

Insulin receptor (IR) proteins were essential intracellular signaling peptides in the insulin action cascade. Insulin receptor substrate proteins (IRS-1and IRS-2) serve and regulate the insulin level in the normal insulin action. The broad role of IRS-1 and IRS-2 in cell growth and survival reveals a common regulatory pathway linking development, somatic growth, fertility, neuronal proliferatio...

Many indigenous medicinal plants possess promising therapeutic properties, but experimental demonstration of specific active compound is lacking. Recent research findings suggest that bioactive fractions derived from a reverberated medicinal plant, namely, Helicteres isora (L.) possesses many therapeutic properties. Different plant extracts are known to cure diarrhea, diabetes, snakebite, weakn...

The different extracts of the roots of Helicteres isora (Family-Sterculiaceae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and butanol extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in ...