Hemophilia is a hemorrhagic disorder with sex-linked inherited pattern, characterized by an inability to amplify coagulation due deficiency in factor VIII (hemophilia A or classic) IX B). Sequencing of the genes involved hemophilia has provided description and record main mutations, as well correlation various degrees severity. Hemorrhagic manifestations are related levels circulating factor, m...

background hemophilia might impact the quality of life (qol) in children and adolescent. this study aimed to assess the quality of life in children with hemophilia and identify the factors that predict their qol. methods it was a cross-sectional study. a consensus sample of twenty-seven male children aged 8-16 years old with hemophilia participated in this study during 2011. the haemo-qol quest...

background: hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors viii (hemophilia a) or ix (hemophilia b) in plasma. we aimed to identify patients with hemophilia in kermanshah, iran and assess the incidence of inhibitors in this population and its associated factors. methods: this study was conducted on patients with hemophilia a and b ...

Hemophilia A is an inherited bleeding disorder caused by deficiency of coagulation factor VIII. It transmitted in X-linked recessive pattern from female carriers to male children. We report the observation a severe hemophilia newborn with history siblings who present hemarthrosis left elbow. The diagnosis was suspected and confirmed through biologic investigations imaging. Therefore, patient pu...

as hemophilia is a chronic bleeding disease and can interfere with daily performance of children, these children require continuous training to prevent bleeding and take timely action (1). since children nurses play an important role in the education of involved children and their selfefficacy and also due to today’s approach which is using educational computer games, the use of educational gam...

  Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with  hemophilia in Kermanshah, Iran and assess the incidence of inhibitors in this population and its associated factors. Methods: This study was conducted on patients with hemophilia...

Hemophilia is an inherited bleeding disorder caused by the lack of a protein necessary for blood clotting. Gene therapy hemophilia involves introduction healthy gene into patient's cells to produce missing protein. There are two main types hemophilia: ex vivo therapy, which extraction from patient, these in laboratory, and reintroduction modified patient; direct delivery body using viral vector...

Hemophilia is one of the most common inherited coagulation disorder; with almost half of the cases presents in the neonatal period with bleeding episodes specially post circumcision, although family history is present in about two third cases. Retroperitoneal hemorrhage is a very rare presentation of hemophilia and to the best of our knowledge has not described yet, as initial presentation of h...

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

bypassing agents are the most commonly used medicines for the treatment of hemophilia patients with inhibitors. the aim of this study is to identify the cost components of management of bleeding vents in hemophilia patients with inhibitors in iran. this study is a cross-sectional study using a bottom-up approach to determine the cost components of treatment of hemophilia patients with inhibitor...