Ionizing radiation transfuses deleterious effects in biological systems. Radiation exposures could be accidental or intended. Efforts for the development of a safe radioprotector have been going over many decades. Several chemical and synthetic compounds have been evaluated to meet the need, however, associated toxicity with useful doses has precluded their use from bench to bed. Presence of nu...

Herbal plants and products represent important source of natural antioxidant offer an alternative to synthetic protectors. Moringa oliefera, a herbal medicinal plant has been screen for their radioprotective activity. For the purpose study male Swiss albino mice were divided into seven groups. The exposed gamma radiation (2.5 Gy 5.0 Gy) also provided mercuric chloride (0.5 ppm) both separately ...

Ionising radiation therapy is a common treatment for different types of cancers. The side effects associated with radiation includes destruction of normal cells, especially the dividing cells. The cells in the gastrointestinal (GI) tract and bone marrow are the primary targets. The GI damage is reflected by early histological changes, functional alterations and symptoms of nausea, vomiting and ...

Because of our increased dependency on the use radiation in areas such as food industry, agriculture, space exploration, diagnostics and treatment various diseases including cancer, possibilities unnecessary exposure to ionizing have considerably increased. Hence, there is a need develop an effective radioprotective agent that can protect against deleterious effects radiation. So far, many synt...

results histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group b as compared to the animals in group a. conclusion in this experimental study, administration of gla one hour before thoracic irradiation may be a protective agent against radiation-indu...

AIM To investigate the survival of laboratory rats after irradiation and to study the cellularity of their bone marrow and the multipotential mesenchymal stem cells (BM-MSCs) in groups treated with or without a new thiol-based radioprotector (GM2011). METHODS Animals were irradiated by a Cobalt gamma source at 6.7 Gy. Treated animals were given i.p. GM2011 30 minutes before and 3 and 7 hours ...

Bone marrow and intestinal damage limits the efficacy of radiotherapy for cancer and can result in death if the whole body is exposed to too high a dose, as might be the case in a nuclear accident or terrorist incident. Identification of an effective nontoxic biological radioprotector is therefore a matter of some urgency. In this study, we show that an orally administered hot-water extract fro...

A majority of potential radioprotective synthetic compounds have demonstrated limited clinical application owing to their inherent toxicity, and thus, the seeking of naturally occurring herbal products, such as ginseng, for their radioprotective capability has become an attractive alternative. In general, ginseng refers to the roots of the species of the genus Panax. As a medicinal herb, ginsen...