The exclusive role of heterocyclic compounds for drug discovery is best documented by the occurrence of a heterocyclic moiety in current drugs; the majority of drugs are heterocyclic compounds. Consequently, a substantial effort has been dedicated to the development of chemistries, both solidand solution-phase, for combinatorial syntheses of heterocyclic libraries. Traditionally, generic combin...

Heterocyclic amines are formed during high temperature cooking of foods such as meat and fish. Although heterocyclic amines are known mutagens and some of them are shown to be carcinogenic to experimental animals, the carcinogenic potential of heterocyclic amines in humans has yet to be established. The most important criteria in determining the relationship between heterocyclic amines and huma...

In the present research, silica bonded n-propyl-1,3,5-triazine-2,4,6-triamine (SPTT) was synthesized by direct incorporation of chloropropyl groups through co-condensation of tetraethyl orthosilicate (TEOS) and 3-chloropropyl trimethoxysilane (CPTMS) and subsequent grafting the melamine onto the propyl groups via simple nucleophilic substitution reaction. The catalyst has been characterized by ...

Transition metal and organic catalysts have established their own domains of excellence. It has been expected that merging the two unique domains should provide complimentary or unprecedented opportunities in converting simple raw materials to functional products. N-heterocyclic carbenes alone are excellent organocatalysts. When used with transition metals such as copper, N-heterocyclic carbene...

Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-l-methyl-6-phenylimidazo(4,5-A|pyridine, produced colon and mammary carcino...

The synthesis of highly enantioenriched α-heterocyclic tertiary alcohols has been achieved via lithiation-borylation of a configurationally stable lithiated carbamate and heterocyclic pinacol boronic esters followed by oxidation. Protodeboronation of the α-heterocyclic tertiary boronic esters using TBAF·3H2O or CsF gave highly enantioenriched 1-pyridyl-1-arylethanes in high er.

A heterocyclic compound is a cyclic compound that has atoms of at least two different elements as members of its ring(s). The counterparts of heterocyclic compounds are homo cyclic compounds although heterocyclic compounds may be inorganic, most contain at least one carbon. Since in organic chemistry non-carbons usually are considered to replace carbon atoms, they are called heteroatoms, meanin...

Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more heteroatoms in their structure. They may be cyclic or non-cyclic in nature. Heterocyclic compounds have a wide range of application. They are predominantly used as pharmaceuticals, agrochemicals, and veterinary products. They also find applications as sanitizers, developers, antioxidants,...

The in vogue N-heterocyclic carbenes (NHCs) have attracted attention largely for its new found popularity in chemical catalysis and also for displaying promising traits in biomedical applications. The current perspective provides an account of our efforts in exploring the utility of N/O-functionalized N-heterocyclic carbenes in these two areas. On the catalysis front, we have employed the N/O-f...

[reaction: see text] The promising utility of triazolyl N-heterocyclic carbene catalysts in umpolung aldehyde chemistry requires a straightforward reliable synthesis from readily available materials. Herein, we describe the synthesis of a variety of triazolyl N-heterocyclic carbene precursors. The reactions commence from commercially available amino acids and proceed in 44-68% overall yields. T...