intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...

one of the main distinctions between geomaterials and other engineering materials is the spatial variation of their properties in different directions. this characteristic of geomaterials -so called heterogeneity- is studied herewith. several spatial distributions are introduced to describe probabilistic variation of geotechnical properties of soils. among all, the absolute normal distribution ...

naturally occurred soil deposits inherit heterogeneity and anisotropy in their strength properties. the main purpose of this paper is to model the soil stratum with anisotropy consideration and spatially varying undrained shear strength by using random field theory coupled with finite difference numerical analysis to evaluate their effect on the bearing capacity of the shallow foundations. in t...

even purified enzyme preparations are often heterogeneous. for example, preparations of aspartate aminotransferase or cytochrome oxidase can consist of several different forms of the enzyme.  for this reason we consider how different the kinetics of the reactions catalysed by a mixture of forms of an enzyme must be to provide some indication of the characteristics of the species present.  based...

background: most of the current brachytherapy treatment planning systems (tps) use the tg-43u1 recommendations for dosimetry in water phantom, not considering the heterogeneity effects. objective: the purpose of this study is developing a method for obtaining correction factors for heterogeneity for cs-137 brachytherapy sources based on pre-calculated mc simulations and interpolation. method: t...

Introduction: Heterogeneity correction is an important parameter in dose calculation for cancer patients where it may be cause inaccuracy in dose calculation as a result of different densities of patients. This study studied the impact of dose calculation of breast cancer patients with and without heterogeneity correction. Material and Methods: Twenty breast cancer patients were treated with Th...

objective(s) while the nucleus accumbens and the striatum have received much attention regarding their roles in stereotyped behaviors, the role of the medial prefrontal cortex (mpfc) has not been investigated to the same degree. few studies have reported the role of the mpfc in dopaminergic induction of locomotor hyperactivity. the mpfc is a heterogeneous area (the anterior cingulated, prelimbi...

Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches w...

Background Hip dysplasia is an abnormality of the hip joint where the socket portion does not fully cover the ball portion, which might increase the risk of joint dislocation. Hip dysplasia may occur at birth or develop in early life. The purpose of the present study was to assess the effect of treatment with Tübingen hip flexion splint for Dev...

This paper studies the effect of the space (distance) between lotteries' outcomes on risk-taking behavior and the shape of estimated utility and probability weighting functions. Previously investigated experimental data shows a significant space effect in the gain domain. As compared to low spaced lotteries, high spaced lotteries are associated with higher risk aversion for high probabilities o...