this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

In the present study sustained release matrix tablets of Theophylline were prepared by direct compression method using different grades and ratios of hydroxy propyl methyl cellulose in presence of ethyl cellulose to examine their influence on tablet properties and drug release profile. Theophylline is used to treat chronic obstructive pulmonary disease (COPD) and asthma. The drug has a narrow t...

The aim of the present work is to design an oral time release tablet by press coating method to achieve a distinct predetermined lag time. In this study Metoprolol tartrate was selected as the model drug. The outer shell was formulated with different weight ratios of Hydroxy propyl methyl cellulose K100M and Ethyl cellulose to achieve a release profile with pre determined lag time. The lag time...

The objective of the present study was formulation and evaluation pulsatile release tablets Atenolol. A tablet system consisting cores which coated with layers swelling rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression appropriate ratios lactose microcrystalline cellulose then sequentially different an inner layer HPMC outer Ethyl Cellulose. effect...

The aim of this study was to formulate and evaluate the novel amoxicillin trihydrate dental gel containing different hydrophilic polymers such as hydroxy propyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxy methyl cellulose (Sod.CMC) and hydroxy propyl cellulose (HPC) in varied concentrations (5, 6, 6 and 9 %) for the treatment of periodontal diseases. Propylene glycol was used...

Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulos...

Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased...

Hydroxy propyl methyl cellulose can be used in the development of different drug delivery technology. Nowadays it is a widely used polymer and different viscosity grade of this polymer is available. The hydrophilic and hydrophobic form (both variants) of this polymer is also available. This study includes a review of this polymer on use in different drug delivery system mosty focusing on more r...

The aim of the present study was to develop a sustained release monolithic system for the low solubile/low dose glipizide, for the treatment of type II diabetes mellitus. The matrices were prepared by dry blending of polymers hydroxy propyl methyl cellulose (HPMC) or erodible Eudragit (ammonio methacrylate copolymers) and other excipients using direct compression method and were characterized u...