Catalytic effect of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate and magnesium stearate in the presence of 50.9% - 76.4% humidity at 318 K on stability of quinapril hydrochloride (QHCl) was examined by HPLC method. The differences in kinetic mechanism of degradation of QHCl were observed. The effect of humidity on QHCl stability in the presence of hydroxypropyl cell...

The relaxation processes in cellulose, methyl cellulose, hydroxypropyl cellulose, and hydroxypropylmethyl cellulose were studied by dielectric spectroscopy. The dielectric spectra for these polysaccharides were measured in the frequency range from 100 Hz to 1 MHz and in the temperature range from 100 to 450 K. The dielectric relaxation data for cellulose, methyl cellulose, hydroxypropylmethyl c...

Magnetic resonance imaging was used to study the diffusion of a water solution of hydrochloric acid (HCl) and sodium hydrochloride (NaOH) into hydroxypropylmethyl cellulose matrices. Polymer in the form of a cylinder was hydrated in a water solvent of pH = 2, 7, and 12 at 37◦C and monitored at equal intervals with a 300 MHz Bruker AVANCE. The spatially resolved spin–spin relaxations times and s...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

The investigation is to study the effect of polymers on compressibility and release of Metoprolol Tartarate from tablet through direct compression. Tablets were prepared by direct compression by mixing with commonly used polymers, Eudragit RL-100, Chitosan, Ethyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose K-100 in 1:1 ratio. The compressibility parameters were estimated...

There are many reports on the application of different hydrocolloids in the production of leavened breads; most of which show positive effects on bread quality. However, there is little information to prove such effect on flat breads. The main aim of this study was to improve the quality of Barbari dough and bread (Iranian flat bread) in terms of texture, taste and general acceptability of fres...

The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the...

In the present work, the drug volume fraction profiles of a colored and very soluble drug, buflomedil pyridoxal phosphate, in the gel layer of initially glassy hydroxypropylmethyl cellulose matrices were studied, using image analysis of pictures of the matrices during swelling and release. The goal was to correlate the drug release kinetics with the dynamic behavior of the drug gradient in the ...

Three layered pellets of budesonide were prepared for colon delivery by the extrusion-spheronization method. The coatings consisted of hydroxypropylmethyl cellulose (HPMC) (as barrier layer), Eudragit E (as rate controlling layer) and hydroxypropylmethyl cellulose acetate succinate (HPMC AS) (as enteric layer). The rate controlling layer was further modified using various pore formers. Dissolut...