نتایج جستجو برای Hyperalgesia

تعداد نتایج: 3450  

2017
Joseph Asaro, Christine A. Robinson, Philip T. Levy,

Visceral hyperalgesia refers to increased pain sensation in response to gastrointestinal sensory stimulus. In neonates with neurological impairments, gabapentin has been successfully used as a treatment for visceral hyperalgesia in neonates. The authors describe a preterm infant with myelomeningocele and persistent neuropathic pain that manifested as irritability, hypertonicity, poor weight gai...

Journal: :Revista brasileira de anestesiologia 2010
Plínio da Cunha Leal, Jefferson Clivatti, João Batista Santos Garcia, Rioko Kimiko Sakata,

BACKGROUND AND OBJECTIVES Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why this can happen is not known. The objective of this review was to describe the mechanisms, factors implicated, and drug modulation. CONTENTS The factors implicated in the development of opioid-induced hyperalgesia (OIH), such as duration of use, dose, and type of opioids ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
M O Urban, G F Gebhart,

Tissue injury is associated with sensitization of nociceptors and subsequent changes in the excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary hyperalgesia. Because central sensitization is considered to reflect plasticity at spinal ...

2012

Introduction Pain is one of the main reasons that people seek medical attention, and it is estimated to affect tens of millions of Americans. Chronic pain management commonly includes the use of opioid type medications. This is in spite of that fact that this class of drugs has well known adverse effects including the development of dependence, tolerance, and addiction. Recently, however, a tro...

Journal: :Arquivos de neuro-psiquiatria 2011
Leonardo Caixeta, Vânia Lúcia Dias Soares, Cândida D Soares,

M.D., Ph.D. Associate Professor, Faculty of Medicine, Federal University of Goiás, Goiânia GO, Brazil. Coordinator of the Behavioral and Cognitive Neurology Unit of the Hospital das Clínicas, Federal University of Goiás, Goiânia GO, Brazil; Neuropsychologist, Member of Behavioral and Cognitive Neurology Unit of the Hospital das Clínicas, Federal University of Goiás, Goiânia GO, Brazil; Speech P...

Journal: :The Medical clinics of North America 2007
Grace Chang, Lucy Chen, Jianren Mao,

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and d...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
X Q Shu, L M Mendell,

Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin. Administration of exogenous NGF either systemically or in the skin causes thermal hyperalgesia within minutes. Mast ce...

Journal: :Progress in brain research 2000
J Sandkühler, J Benrath, C Brechtel, R Ruscheweyh, B Heinke,

Introduction ?#1 Hyperalgesia and allodynia often aggravate pain for variable periods of time after trauma, surgery or inflammation. Pain that is induced by normally nonpainful stimuli (allodynia) or abnormally intense pain elicited by noxious stimuli (hyperalgesia) may be the consequence of an increased sensitivity of nociceptors (peripheral sensitization) or may be due to an increased respons...

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