gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. hypercholesterolemia is a quantitativ...

the effects of ethanolic and aqueous extracts of rheum ribs l. (rr) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. to induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. both the et...

the present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. in enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. oland p

Background: The prevalence of hypercholesterolemia is increasing globally. It is associated with a significant risk of developing type 2 diabetes mellitus and cardiovascular diseases. The aim of the current study was to explore the relationship of nutrients patterns and other lifestyle-related factors with the presence of hypercholesterolemia in a representative population of Iran. Methods: Die...

Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...

background: atherosclerosis is one of the most important cardiovascular diseases that involve vessels through the development of fatty streaks and plaques. plant?based compounds can help treat or prevent atherosclerosis through affecting the involved factors. the main purpose of this review article is to investigate and introduce medicinal plants and their potential activities regarding antioxi...

in this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (ldl-c) on the plasma lipid profile. in a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with tcholesterol ≥220 mg/dl, ldl-c ≥ 160 mg/dl, and triglyceride ≤ 350 mg/dl ...

objective(s)cardiovascular disease causes a major clinical problem in patients with end stage renal disease. since metabolic acidosis is very common in patients with end stage renal disease, we aimed to investigate the effect of experimentally-induced metabolic acidosis on serum lipid profile and aortic fatty streak (fs) formation in normal and high-cholesterol fed rabbits.materials and methods...

familial hypercholesterolemia (fh) is an inherited common autosomal mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. fh is characterized by severely elevated levels of low-density lipoprotein cholesterol (ldl-c), which result in surplus deposition of cholesterol in tissues. this condition leads to premature at hero sclerosis and early-onset of coronary hear...