Mutations of germ-cell line TP53 gene are mainly reported in Li–Fraumeni syndrome(LFS). LFS-associated breast cancers are both hormone receptor and human epidermal growth factor receptor 2 positive. The purpose of this study is presentation of one case of LFS, associated with familial hyperlipidemias. A 52-year-old woman referred to clinic of oncology with a pain in the left breast. Her patholo...

The discovery of the key enzymes, receptors, and transporters in cholesterol biosynthesis has enabled us to assemble fragments of knowledge concerning lipids and lipoproteins into dynamic pathways, leading to the development of a multitude of lipid-lowering drugs. After a brief recapitulation of the pathways of cholesterol metabolism and the dermatologic manifestations of lipid derangement, we ...

conclusions it seems that cohort studies with larger sample sizes on the relationship between periodontitis and cholesterol level (total, hdl, ldl) are necessary. background many studies show that periodontitis is a risk factor for serum lipid levels increase. on the other hand, the increase of serum lipids is clearly a risk factor for cardiovascular diseases. objectives the current study aimed...