INTRODUCTION Adult type hypolactasia is the most common non allergic abnormal reaction to food. Its frequency increases with age. Hypolactasia creates the risk of decreased milk consumption, which could be the cause of lowered bone density, osteoporosis and fractures. The aim of the research was to estimate the frequency of hypolactasia among Szczecin's citizens. MATERIAL AND METHODS 200 rand...

BACKGROUND Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa. Lactase non-persistence is the most common phenotype in humans, except in northwestern Europe with its long history of pastoralism and milking. We had previously shown association of LCT -13910C>T polymorphism...

Gastrointestinal symptoms are frequent in the adult working-age population. Sufferers often relate them to ingested food substances, especially cow’s milk. The purpose of this study was to evaluate subjective food-related gastrointestinal symptoms and their relation to cow’s milk. This was done by determining the genotype of adult-type hypolactasia, measuring antibodies against milk protein, an...

OBJECTIVES Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (LCT) at chromosome 2 has been s...

Adult type hypolactasia, the genetically programmed down-regulation of lactase enzyme activity in the intestinal wall after weaning, is a common condition worldwide, except for in northwestern Europe, where the prevalence is less than 10%. Lactose intolerant individuals complain of abdominal cramps, bloating, distention, flatulence and diarrhea after milk or lactose-containing food ingestion. T...

CONTEXT Genotyping of single nucleotide polymorphism (SNP C/T(-13910)) located upstream of the lactase gene is used to determine adult-type hypolactasia/lactase persistence in North-European Caucasian subjects. The applicability of this polymorphism has been studied by comparing it with the standard diagnostic methods in different populations. OBJECTIVE To compare the lactose hydrogen breath ...

Background/Aims: Adult-type hypolactasia (primary lactose malabsorption) affects most of world’s human population and limits the use of fresh milk due to lactose intolerance. The diagnosis of adult-type hypolactasia has been difficult to establish because of unsatisfactory diagnostic methods. C/T-13910 single nucleotide polymorphism residing 13910 base pairs from the 59 end of the lactase gene ...

BACKGROUND/AIMS Adult-type hypolactasia (primary lactose malabsorption) affects most of world's human population and limits the use of fresh milk due to lactose intolerance. The diagnosis of adult-type hypolactasia has been difficult to establish because of unsatisfactory diagnostic methods. C/T(-13910) single nucleotide polymorphism residing 13910 base pairs from the 5' end of the lactase gene...

Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immunologically reactive lactase protein was demonstrated irrespective of the lacta...

objective(s) primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. lactase non-persistence is inherited as an autosomal recessive trait. a dna variant, single nucleotide polymorphism c/t−13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (lct) at chromosome 2 has been...